TGF‐β receptors Journal Article
| Authors: | Massagué, J.; Andres, J.; Attisano, L.; Cheifetz, S.; López-Casillas, F.; Ohtsuki, M.; Wrana, J. L. |
| Article Title: | TGF‐β receptors |
| Abstract: | The nature and role of cell surface proteins that bind members of the TGF‐β family has been investigated. TGF‐β, activins, and BMPs each bind to receptors of 55 kDa (type I) and 70 kDa (type II). In the TGF‐β system, these receptors are implicated in the mediation of multiple responses. A member of the type II receptor family has been cloned that encodes four alternatively spliced versions of a transmembrane serine/threonine kinase receptor related to the recently cloned mouse activin receptor and C‐elegans daf‐1 gene. Inhibitors of serine/threonine kinase activity block transcriptional and growth inhibitory responses to TGF‐β. In addition to the signaling receptors, many cell types express the TGF‐β binding proteoglycan betaglycan. Betaglycan has been purified, molecularly cloned, and shown to bind TGF‐β via its core protein and basic fibroblast growth factor via its heparan sulfate chains. In addition to receptors I and II and betaglycan, some cells express a newly identified set of membrane proteins that specifically bind either TGF‐β1 or TGF‐β2. Three of the four isoform‐restricted binding proteins are bound to the membrane via phospholipid anchors. Like betaglycan, these proteins might function to regulate the interaction between TGF‐β and their target cells. © 1992 Wiley‐Liss, Inc. Copyright © 1992 Wiley‐Liss, Inc. |
| Keywords: | signal transduction; core protein; nonhuman; conference paper; protein domain; animal; enzyme inhibition; transforming growth factor beta; genetic transcription; protein serine threonine kinase; amino acid sequence; molecular sequence data; membrane protein; transforming growth factor beta1; receptors, transforming growth factor beta; binding protein; heparan sulfate; receptor binding; growth inhibition; receptors, cell surface; binding proteins; cloning; receptor subtype; transforming growth factor beta2; basic fibroblast growth factor; growth factor receptor; glycan; activin; cell surface proteins; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; betaglycan |
| Journal Title: | Molecular Reproduction and Development |
| Volume: | 32 |
| Issue: | 2 |
| ISSN: | 1040-452X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1992-06-01 |
| Start Page: | 99 |
| End Page: | 104 |
| Language: | English |
| DOI: | 10.1002/mrd.1080320204 |
| PUBMED: | 1322148 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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