Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors Journal Article

  


Authors: Attisano, L.; Cárcamo, J.; Ventura, F.; Weis, F. M. B.; Massagué, J.; Wrana, J. L.
Article Title: Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors
Abstract: Transforming growth factor β (TGFβ) and activin each bind to pairs of membrane proteins, known as receptor types I and II, that associate to form a signaling complex. We report that TSR-I and ActR-I, two human transmembrane serine/threonine kinases distantly related to TGFβ and activin type II receptors, act as type I receptors for these factors. TSR-I is a type I receptor shared by TGFβ and activin, whereas ActR-I is an activin type I receptor. ActR-I, but not TSR-I, signals a particular transcriptional response in concert with activin type II receptors. The results indicate that type I receptors are transmembrane protein kinases that associate with type II receptors to generate diverse heteromeric serine/threonine kinase complexes of different signaling capacities. © 1993.
Keywords: signal transduction; controlled study; human cell; nonhuman; comparative study; binding affinity; animal cell; transforming growth factor beta; animalia; gene expression regulation; cloning, molecular; molecular sequence data; sequence homology, amino acid; species specificity; rna, messenger; sequence alignment; protein-serine-threonine kinases; membrane protein; protein transport; receptors, transforming growth factor beta; ligands; dna primers; membrane transport; receptor binding; dna, complementary; receptors, cell surface; receptors, growth factor; activin; activins; human; priority journal; article; inhibins; support, non-u.s. gov't; support, u.s. gov't, non-p.h.s.; macromolecular systems; activin receptors
Journal Title: Cell
Volume: 75
Issue: 4
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 1993-11-19
Start Page: 671
End Page: 680
Language: English
DOI: 10.1016/0092-8674(93)90488-c
PUBMED: 8242742
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027525105&doi=10.1016%2f0092-8674%2893%2990488-C&partnerID=40&md5=18cebbafd877fbd7a5c434f393236805
Notes: Source: Scopus
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MSK Authors
  1. Juan O Carcamo
    31 Carcamo
  2. Joan Massague
    388 Massague
  3. Jeff Wrana
    39 Wrana
  4. Liliana Attisano
    30 Attisano
  5. Francese Ventura
    11 Ventura
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