Drosophila dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family Journal Article

  

Authors:	Letsou, A.; Arora, K.; Wrana, J. L.; Simin, K.; Twombly, V.; Jamal, J.; Staehling-Hampton, K.; Hoffmann, F. M.; Gelbart, W. M.; Massagué, J.; O'Connor, M. B.
Article Title:	Drosophila dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family
Abstract:	Signaling by TGFβ-related factors requires ligand-induced association between type I and type II transmembrane serine/threonine kinases. In Drosophila, the saxophone (sax) and thick veins (tkv) genes encode type I receptors that mediate signaling by decapentaplegic (dpp), a member of the bone morphogenetic protein (BMP) subgroup of TGFβ-type factors. In this report, we demonstrate that the Drosophila punt gene encodes atr-II, a previously described type II receptor that on its own is able to bind activin but not BMP2, a vertebrate ortholog of dpp. Mutations in punt produce phenotypes similar to those exhibited by tkv, sax, and dpp mutants. Furthermore, punt will bind BMP2 in concert with tkv or sax, forming complexes with these receptors. We suggest that punt functions as a type II receptor for dpp and propose that BMP signaling in vertebrates may also involve sharing of type II receptors by diverse ligands. © 1995.
Keywords:	signal transduction; controlled study; nonhuman; animal cell; animal; animal tissue; bone morphogenetic protein; transforming growth factor beta; cell line; drosophila; transcription, genetic; transfection; protein serine threonine kinase; cercopithecus aethiops; dna; cell strain cos1; receptors, transforming growth factor beta; molecular interaction; cell interaction; cell communication; receptor binding; multigene family; cell surface receptor; receptors, cell surface; genes, lethal; receptors, growth factor; genes, insect; crosses, genetic; transformation, genetic; fertilization; activin; dna transfection; male; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; activin receptors; insect hormones
Journal Title:	Cell
Volume:	80
Issue:	6
ISSN:	0092-8674
Publisher:	Cell Press
Date Published:	1995-03-24
Start Page:	899
End Page:	908
Language:	English
DOI:	10.1016/0092-8674(95)90293-7
PUBMED:	7697720
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028907069&doi=10.1016%2f0092-8674%2895%2990293-7&partnerID=40&md5=132f22910a7a04dadb465054bc213fb9
Notes:	Article -- Export Date: 28 August 2018 -- Source: Scopus

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