Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor Journal Article

  

Authors:	Penton, A.; Chen, Y.; Staehling-Hampton, K.; Wrana, J. L.; Attisano, L.; Szidonya, J.; Cassill, J. A.; Massagué, J.; Hoffmann, F. M.
Article Title:	Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor
Abstract:	Drosophila sequences at chromosomal positions 25D (Brk25D) and 43E (Brk43E) are similar to the TGFβ type I receptor serine/threonine kinases and are expressed broadly during embryogenesis. Brk25D binds dpp protein and bone morphogenetic protein 2 with high affinity. Mutations affecting Brk25D map to the gene thick veins and block the expression of two decapentaplegic-responsive (dpp-responsive) genes, dpp and labial, in the embryonic midgut. Defects in Brk25D receptor function combined with reduced expression of dpp ligand produce mutant phenotypes in the embryo and adult. Brk43E is the product of the gene saxophone, which also interacts with dpp. We conclude that dpp signaling in vivo is mediated by at least two receptors, Brk25D and Brk43E. © 1994.
Keywords:	signal transduction; gene mutation; gene sequence; mutation; nonhuman; proteins; protein analysis; animals; gene expression; bone morphogenetic protein; transforming growth factor beta; protein binding; drosophila; embryo development; protein serine threonine kinase; gene expression regulation; cloning, molecular; gene mapping; amino acid sequence; molecular sequence data; rna, messenger; sequence alignment; protein-serine-threonine kinases; receptors, transforming growth factor beta; base sequence; drosophila proteins; dna, complementary; receptors, cell surface; sequence analysis, dna; bone morphogenetic proteins; genes, insect; membrane receptor; priority journal; article; insect hormones
Journal Title:	Cell
Volume:	78
Issue:	2
ISSN:	0092-8674
Publisher:	Cell Press
Date Published:	1994-07-29
Start Page:	239
End Page:	250
Language:	English
DOI:	10.1016/0092-8674(94)90294-1
PROVIDER:	scopus
PUBMED:	8044838
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028141433&doi=10.1016%2f0092-8674%2894%2990294-1&partnerID=40&md5=b39a7d56400e3a9437f83bc3b6d14882
Notes:	Export Date: 14 January 2019 -- Article -- Source: Scopus

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