Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors Journal Article
| Authors: | Halfon, M. S.; Carmena, A.; Gisselbrecht, S.; Sackerson, C. M.; Jiménez, F.; Baylies, M. K.; Michelson, A. M. |
| Article Title: | Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors |
| Abstract: | Ras signaling elicits diverse outputs, yet how Ras specificity is generated remains incompletely understood. We demonstrate that Wingless (Wg) and Decapentaplegic (Dpp) confer competence for receptor tyrosine kinase-mediated induction of a subset of Drosophila muscle and cardiac progenitors by acting both upstream of and in parallel to Ras. In addition to regulating the expression of proximal Ras pathway components, Wg and Dpp coordinate the direct effects of three signal-activated (dTCF, Mad, and Pointed - functioning in the Wg, Dpp, and Ras/MAPK pathways, respectively) and two tissue-restricted (Twist and Tinman) transcription factors on a progenitor identity gene enhancer. The integration of Pointed with the combinatorial effects of dTCF, Mad, Twist, and Tinman determines inductive Ras signaling specificity in muscle and heart development. |
| Keywords: | signal transduction; unclassified drug; dna-binding proteins; proto-oncogene proteins; nonhuman; animal cell; animals; nerve tissue proteins; transcription factor; drosophila; eye proteins; homeodomain proteins; cell lineage; animalia; transcription factors; protein tyrosine kinase inhibitor; gene expression regulation; gene expression regulation, developmental; bacterial proteins; transcription regulation; stem cells; ras protein; binding sites; molecular interaction; receptor protein-tyrosine kinases; ras proteins; repressor proteins; transcription factor twist; mesoderm; drosophila proteins; heart; body patterning; oncogene ras; myocardium; heart development; muscle, skeletal; muscle development; enhancer elements (genetics); priority journal; article; insect proteins; decapentaplegic protein; protein wg; transcription factor tinman |
| Journal Title: | Cell |
| Volume: | 103 |
| Issue: | 1 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2000-09-29 |
| Start Page: | 63 |
| End Page: | 74 |
| Language: | English |
| PUBMED: | 11051548 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S0092-8674(00)00105-7 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
