Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis Journal Article

  


Authors: Verheij, M.; Bose, R.; Lin, X. H.; Yao, B.; Jarvis, W. D.; Grant, S.; Birrer, M. J.; Szabo, E.; Zon, L. I.; Kyriakis, J. M.; Haimovitz-Friedman, A.; Fuks, Z.; Kolesnick, R. N.
Article Title: Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
Abstract: The induction of programmed cell death, or apoptosis, involves activation of a signalling system, many elements of which remain unknown. The sphingomyelin pathway, initiated by hydrolysis of the phospholipid sphingomyelin in the cell membrane to generate the second messenger ceramide, is thought to mediate apoptosis in response to tumour-necrosis factor (TNF)-α, to Fas ligand and to X-rays. It is not known whether it plays a role in the stimulation of other forms of stress-induced apoptosis. Given that environmental stresses also stimulate a stress activated protein kinase (SAPK/JNK), the sphingomyelin and SAPK/JNK signalling systems may be coordinated in induction of apoptosis. Here we report that ceramide initiates apoptosis through the SAPK cascade and provide evidence for a signalling mechanism that integrates cytokine- and stress-activated apoptosis.
Keywords: signal transduction; human cell; mutation; animals; cell death; apoptosis; protein kinases; cell line; enzyme activation; tumor cells, cultured; transfection; tumor necrosis factor alpha; tumor necrosis factor-alpha; protein-serine-threonine kinases; stress; cattle; sphingosine; mitogen-activated protein kinases; protein kinase; mitogen-activated protein kinase kinases; x ray; ceramide; ceramides; sphingomyelin; second messenger; jnk mitogen-activated protein kinases; map kinase kinase 4; phospholipid metabolism; proto-oncogene proteins c-jun; humans; human; priority journal; article; mitogen-activated protein kinase 9
Journal Title: Nature
Volume: 380
Issue: 6569
ISSN: 0028-0836
Publisher: Nature Publishing Group  
Date Published: 1996-03-07
Start Page: 75
End Page: 79
Language: English
DOI: 10.1038/380075a0
PUBMED: 8598911
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0347537940&doi=10.1038%2f380075a0&partnerID=40&md5=328dadcd56c2797a2604485df09db83d
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Zvi Fuks
    427 Fuks
  2. Xinhua Lin
    6 Lin
  3. Adriana Haimovitz-Friedman
    170 Haimovitz-Friedman
  4. Richard N Kolesnick
    299 Kolesnick
Related MSK Work