Stress signals for apoptosis: Ceramide and c-Jun kinase Journal Article


Authors: Basu, S.; Kolesnick, R.
Article Title: Stress signals for apoptosis: Ceramide and c-Jun kinase
Abstract: Mammalian systems respond to environmental stress by either adapting or undergoing programmed cell death. While there is general agreement that the caspase family of proteases serve as the effectors of the apoptotic death response, the signaling apparatus involved in the decision to activate the caspase system is less clear. In the past few years, the sphingomyelin and c-Jun Kinase (JNK)/Stress-activated Protein Kinase (SAPK) pathways have been linked to the death response in many cellular systems. These signaling systems are found throughout the animal kingdom, and ceramide signaling is conserved through yeast. Since yeast do not undergo apoptosis, the sphingomyelin pathway appears evolutionarily older than the caspase-mediated death programs. While recent reviews by several groups have broadly surveyed ceramide signaling in apoptosis, this paper examines the role of sphingomyelinases and the JNK/SAPK pathway in coordinate signaling of apoptosis.
Keywords: signal transduction; nonhuman; animal cell; mouse; mammalia; animals; apoptosis; stress activated protein kinase; caspase; caspases; animalia; stress; yeast; mitogen-activated protein kinases; oxidoreductases; ceramide; ceramides; sphingomyelin phosphodiesterase; sphingomyelin; jnk mitogen-activated protein kinases; jnk; ca(2+)-calmodulin dependent protein kinase; humans; human; priority journal; article
Journal Title: Oncogene
Volume: 17
Issue: 25
ISSN: 0950-9232
Publisher: Nature Publishing Group  
Date Published: 1998-12-24
Start Page: 3277
End Page: 3285
Language: English
PUBMED: 9916990
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
Citation Impact
MSK Authors
  1. Richard N Kolesnick
    299 Kolesnick
  2. Subham   Basu
    7 Basu