Ceramide signaling in apoptosis Journal Article
| Authors: | Haimovitz-Friedman, A.; Kolesnick, R. N.; Fuks, Z. |
| Article Title: | Ceramide signaling in apoptosis |
| Abstract: | The sphingomyelin pathway is a ubiquitous, evolutionarily conserved signaling system initiated by hydrolysis of the plasma membrane phospholipid sphingomyelin to generate ceramide. Ceramide acts as a second messenger in activating the apoptotic cascade. Diverse cytokine receptors and environmental stresses utilize ceramide to signal apoptosis. In several cell systems ceramide links to the stress-activated protein kinase (SAPK)/c-jun kinase (JNK) cascade to signal apoptosis. The engagement of the sphingomyelin pathway in signaling apoptosis is tightly regulated by anti-apoptotic control mechanisms, and the balance between pro- and anti-apoptotic systems determines the magnitude of the apoptotic response in vitro and in vivo. This review describes the known elements and molecular ordering of ceramide-mediated apoptosis and the anti-apoptotic mechanisms that regulate its expression. Understanding of pro- and anti-apoptotic signaling involved in ceramide-mediated apoptosis and the modes of their co-ordinated function may yield opportunities for pharmacological interventions with potential for clinical applications. |
| Keywords: | signal transduction; review; apoptosis; caspases; fibroblast growth factor 2; cell membrane; proteinase; sphingosine; environmental factor; protein kinase; hydrolysis; ceramide; ceramides; sphingomyelin; second messenger; cytokine receptor; membrane phospholipid; caenorhabditis elegans proteins; basic fibroblast growth factor; cysteine endopeptidases; sphingomyelins; humans; priority journal; oncogene c jun; caspase 1 |
| Journal Title: | British Medical Bulletin |
| Volume: | 53 |
| Issue: | 3 |
| ISSN: | 0007-1420 |
| Publisher: | Oxford University Press |
| Date Published: | 1997-01-01 |
| Start Page: | 539 |
| End Page: | 553 |
| Language: | English |
| PUBMED: | 9374036 |
| PROVIDER: | scopus |
| DOI: | 10.1093/oxfordjournals.bmb.a011629 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 17 March 2017 -- Source: Scopus |
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