Differential inhibition of radiation-induced apoptosis Journal Article
| Authors: | Haimovitz-Friedman, A.; Kolesnick, R. N.; Fuks, Z. |
| Article Title: | Differential inhibition of radiation-induced apoptosis |
| Abstract: | The most common mechanism by which radiation kills cells is the induction of DNA double-strand breaks that results in the loss of cell proliferation. Even though apoptosis is increasingly identified in experimental systems in vitro and in vivo, it is still generally regarded as a rare mode of radiation-induced cell kill with minor relevance for the clinical effects of radiation. This review will focus on pro- and antiapoptotic signaling that affects the apoptotic outcome in irradiated mammalian cells. In particular, we will concentrate on the sphingomyelin/ceramide signal transduction pathway which is involved in initiation of stress-induced apoptosis in a variety of normal and neoplastic cells. We will also discuss the crosstalk between the sphingomyelin/ceramide pathway and the protein kinase C pathway which constitutes an antiapoptotic pathway, and the potential for pharmacological modulation to increase the fraction of apoptotic cells undergoing apoptosis after radiation exposure. |
| Keywords: | signal transduction; conference paper; mammalia; animals; dna damage; cell survival; apoptosis; enzyme activation; radiation injury; radiation exposure; dna strand breakage; fibroblast growth factor 2; double stranded dna; cell damage; irradiation; protein kinase c; cell killing; ceramide; sphingomyelin; basic fibroblast growth factor; humans |
| Journal Title: | Stem Cells |
| Volume: | 15 |
| Issue: | Suppl. 1 |
| ISSN: | 1066-5099 |
| Publisher: | AlphaMed Press |
| Date Published: | 1997-02-01 |
| Start Page: | 43 |
| End Page: | 47 |
| Language: | English |
| PUBMED: | 9368285 |
| PROVIDER: | scopus |
| DOI: | 10.1002/stem.5530150708 |
| DOI/URL: | |
| Notes: | Conference Paper -- Export Date: 17 March 2017 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work