Structure and characterization of the gene encoding a mouse kappa(3)-related opioid receptor Journal Article
| Authors: | Pan, Y. X.; Xu, J.; Pasternak, G. W. |
| Article Title: | Structure and characterization of the gene encoding a mouse kappa(3)-related opioid receptor |
| Abstract: | A genomic clone comprising the entire cDNA sequence encoding a mouse kappa3-related opioid receptor (KOR-3) was isolated by screening a mouse genomic library with a radiolabeled mouse KOR-3 cDNA probe. Sequence analysis of the genomic clone indicates that the KOR-3 gene contains five exons separated by four introns. The transcription start point (tsp) of KOR-3 was mapped by primer extension analysis of RNAs synthesized either in vivo or in vitro. A TATA-box and several potential regulatory elements, including five GRE sites, four NF-E1 binding sites and one MRE site, are present in the 2 kb of 5'-flanking region. A putative poly(A) signal (AATAAA) is found in the 3'-flanking region. |
| Keywords: | controlled study; human cell; exon; nonhuman; mouse; intron; gene library; molecular cloning; messenger rna; nucleotide sequence; transcription; binding site; dna flanking region; receptor gene; complementary dna; gene structure; start codon; tata box; regulator gene; kappa opiate receptor; nuclear factor; polyadenylic acid; human; priority journal; article; kor-3; hormone responsive element |
| Journal Title: | Gene |
| Volume: | 171 |
| Issue: | 2 |
| ISSN: | 0378-1119 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1996-06-01 |
| Start Page: | 255 |
| End Page: | 260 |
| Language: | English |
| DOI: | 10.1016/0378-1119(95)00890-x |
| PUBMED: | 8666282 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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