Structural analysis of TL genes of the mouse Journal Article
| Authors: | Obata, Y.; Chen, Y. T.; Stockert, E.; Old, L. J. |
| Article Title: | Structural analysis of TL genes of the mouse |
| Abstract: | Three Tla region-specific probes have been generated from the BALB/c genomic cosmid clone C6.3. One probe, pTL1, corresponds to 3' sequences of a thymus leukemia (TL)-encoding gene, whereas pTL2 and pTL3 detect noncoding flanking sequences. The TL specificity of pTL1 was demonstrated by studies of RNA from thymocytes of TL+ and TL- mouse strains and from TL+ and TL- leukemias; presence/absence of pTL1+ transcripts correlated with presence/absence of TL antigens detected serologically. Nine Tla haplotypes were defined by restriction fragment polymorphism with pTL1, and the number of TL genes has been estimated to be ≥4 in Tlaa, Tla(c) and Tlae mice, ≥3 in Tla(d) mice, and ≥2 in Tlab and Tla(f) mice. A TL-encoding gene (C25.1) from the C57BL/6TL+ leukemia ERLD has been cloned and sequenced, and the exon/intron organization of C25.1 has been deduced from the structure pTL+ cDNA clones and from the known organization of H-2 genes. The major structural differences between TL and H-2 genes are in exons coding for the cytoplasmic domain. |
| Keywords: | unclassified drug; nonhuman; mouse; heredity; thymus; leukemogenesis; gene structure; differentiation antigen; priority journal; article; thymus leukemia antigen |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 82 |
| Issue: | 16 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 1985-08-01 |
| Start Page: | 5475 |
| End Page: | 5479 |
| Language: | English |
| DOI: | 10.1073/pnas.82.16.5475 |
| PROVIDER: | scopus |
| PMCID: | PMC391145 |
| PUBMED: | 2410925 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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