Radioimmunotherapy with alpha-emitting nuclides Journal Article

  


Authors: McDevitt, M. R.; Sgouros, G.; Finn, R. D.; Humm, J. L.; Jurcic, J. G.; Larson, S. M.; Scheinberg, D. A.
Article Title: Radioimmunotherapy with alpha-emitting nuclides
Abstract: This review discusses the application of alpha particle-emitting radionuclides in targeted radioimmunotherapy. It will outline the production and chemistry of astatine-211, bismuth-212, lead-212, actinium-225, bismuth-213, fermium-255, radium-223 and terbium-149, which at present are the most promising alpha-emitting isotopes available for human clinical use. The selective cytotoxicity offered by alpha particle-emitting radioimmunoconstructs is due to the high linear energy transfer and short particle path length of these radionuclides. Based upon the pharmacokinetics of alpha particle-emitting radioimmunoconstructs, both stochastic and conventional dosimetric methodology is discussed, as is the preclinical and initial clinical use of these radionuclides conjugated to monoclonal antibodies for the treatment of human neoplasia.
Keywords: review; nonhuman; drug targeting; cancer radiotherapy; methodology; animals; cancer immunotherapy; statistics; radiotherapy dosage; cytotoxicity; cancer model; monoclonal antibody; immunoglobulin g; drug distribution; dosimetry; tumor cell; radiopharmaceutical agent; clinical research; radioisotope; half life time; radioimmunotherapy; radioisotopes; radiochemistry; drug manufacture; alpha radiation; bismuth; alpha particles; actinium; linear energy transfer; astatine 211; chelating agent; actinium-225; radium; lead 212; terbium; humans; human; alpha particle-emitting radionuclides; astatine-211; bismuth-212; bismuth-213; high linear energy transfer; fermium
Journal Title: European Journal of Nuclear Medicine
Volume: 25
Issue: 9
ISSN: 0340-6997
Publisher: Springer Verlag  
Date Published: 1998-09-01
Start Page: 1341
End Page: 1351
Language: English
DOI: 10.1007/s002590050306
PUBMED: 9724387
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031715792&doi=10.1007%2fs002590050306&partnerID=40&md5=c6a24580539e4e195f9aa9b1404f0304
Notes: Review -- Export Date: 12 December 2016 -- Source: Scopus
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MSK Authors
  1. George Sgouros
    146 Sgouros
  2. Ronald D Finn
    279 Finn
  3. Michael R Mcdevitt
    144 Mcdevitt
  4. Joseph G Jurcic
    134 Jurcic
  5. David Scheinberg
    499 Scheinberg
  6. John Laurence Humm
    433 Humm
  7. Steven M Larson
    959 Larson
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