Small-scale dosimetry: Challenges and future directions Journal Article
| Authors: | Roeske, J. C.; Aydogan, B.; Bardies, M.; Humm, J. L. |
| Article Title: | Small-scale dosimetry: Challenges and future directions |
| Abstract: | The increased specificity of targeting agents has resulted in an interest in the use of radionuclides that emit particulate radiation: alpha particles, beta particles and Auger electrons. The potential advantage of these radionuclides is the ability to deliver therapeutic doses to individual tumor cells while minimizing the dose to the surrounding normal tissues. However, the dosimetry of these radionuclides is challenging because the dose must be characterized on a scale that is comparable to the range of these emissions, ie, millimeters for beta particles, micrometers for alpha particles, and nanometers for Auger electrons to. In this review, each class of particulate emitter is discussed along with the associated dosimetric techniques unique to calculating dose on these scales. The limitations of these approaches and the factors that hinder the clinical use of small-scale dosimetry are also discussed. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | unclassified drug; review; nonhuman; radiation dose; ibritumomab tiuxetan; nuclear magnetic resonance imaging; positron emission tomography; technetium 99m; cell survival; models, biological; analytic method; algorithms; simulation; molecular mechanics; b cell lymphoma; iodine 125; iodine 131; radioactive iodine; drug mechanism; algorithm; dosimetry; radiopharmaceutical agent; forecasting; radiosensitivity; computer simulation; nuclear medicine; cell nucleus; radiometry; relative biological effectiveness; radioisotope; second cancer; body burden; radioimmunotherapy; etidronic acid tc 99m; single photon emission computer tomography; indium 111; radioisotopes; radiation dose distribution; stochastic model; dose calculation; mathematical computing; follicular lymphoma; radioisotope decay; gallium 67; thallium 201; molecular model; x ray; monte carlo method; electron; radiobiology; alpha radiation; yttrium 90; linear energy transfer; astatine 211; microdosimetry; samarium 153; pertechnetic acid tc 99m; antibody y 90; bismuth 212; bromine 77; bromine 80m; bromodeoxyuridine br 80m; broxuridine br 77; helium; idoxuridine i 125; iodine 123; pyrophosphate technetium tc 99m; rhenium 188; tellurium 123; tellurium 125; terbium 149; auger electron spectroscopy; fourier transformation; lethal dose |
| Journal Title: | Seminars in Nuclear Medicine |
| Volume: | 38 |
| Issue: | 5 |
| ISSN: | 0001-2998 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2008-09-01 |
| Start Page: | 367 |
| End Page: | 383 |
| Language: | English |
| DOI: | 10.1053/j.semnuclmed.2008.05.003 |
| PUBMED: | 18662558 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 17 November 2011" - "CODEN: SMNMA" - "Source: Scopus" |
