Cyclotron production of cesium radionuclides as analogues for francium-221 biodistribution Journal Article

Authors: Finn, R.; Mcdevitt, M.; Sheh, Y.; Lom, C.; Qiao, J.; Cai, S.; Burnazi, E.; Nacca, A.; Pillarsetty, N.; Jaggi, J.; Scheinberg, D.
Article Title: Cyclotron production of cesium radionuclides as analogues for francium-221 biodistribution
Abstract: In our clinical investigations focussing on improved therapeutic treatment of specific tumors we have concentrated on a targeted therapy approach utilizing designed radiolabeled monoclonal antibodies as the cytotoxic reagent. The physical characteristics of the alpha particle emitting radionuclide bismuth-213 including the short half-life of 45.6 min, has shown promise for the treatment of specific cancers such as leukemias and lymphomas or micrometastatic carcinomas. In an effort to increase the cytocidal effect of the HuM195, a humanized monoclonal antibody carrier to the CD33 antigen expressed on leukemia cells, our focus is directed toward an "internal" nano-generator composed of Ac-225 radionuclide, the parent of the bismuth-213. The actinium-225 radionuclide decays through several short-lived, alpha emitting daughters including francium-221, astatine-217 and bismuth-213. In order to study the biodistribution and the pharmacokinetics of the individual daughter nuclide, francium-221, the cyclotron production and separation of cesium radionuclides, specifically cesium-132, from a natural xenon gas target was undertaken. The choice of cesium as an analogue for francium was predicated upon both elements being in Group 1A alkali metals and cesium radionuclide possesses a sufficient half-life to allow biodistribution studies to be performed. The preliminary experimental results of this investigation are presented. © 2005 Elsevier B.V. All rights reserved.
Keywords: cytology; monoclonal antibodies; radiology; tumors; radioisotopes; cyclotrons; pharmacokinetics; biodistribution; toxic materials; cesium; cesium radioisotopes; francium-221; leukemia cells
Journal Title: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume: 241
Issue: 1-4
ISSN: 0168-583X
Publisher: Elsevier B.V.  
Date Published: 2005-12-01
Start Page: 649
End Page: 651
Language: English
DOI: 10.1016/j.nimb.2005.07.162
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 3" - "Export Date: 24 October 2012" - "CODEN: NIMBE" - "Source: Scopus"
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MSK Authors
  1. Angelo Nacca
    6 Nacca
  2. Jaspreet Jaggi
    21 Jaggi
  3. Ronald D Finn
    252 Finn
  4. Michael R Mcdevitt
    118 Mcdevitt
  5. Shangde Cai
    42 Cai
  6. Eva M Burnazi
    13 Burnazi
  7. Yiauchung Sheh
    8 Sheh
  8. Calvin A Lom
    5 Lom
  9. Jing Qiao
    2 Qiao