Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications Journal Article


Authors: Miederer, M.; Scheinberg, D. A.; McDevitt, M. R.
Article Title: Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications
Abstract: Alpha particle-emitting isotopes have been proposed as novel cytotoxic agents for augmenting targeted therapy. Properties of alpha particle radiation such as their limited range in tissue of a few cell diameters and their high linear energy transfer leading to dense radiation damage along each alpha track are promising in the treatment of cancer, especially when single cells or clusters of tumor cells are targeted. Actinium-225 (225Ac) is an alpha particle-emitting radionuclide that generates 4 net alpha particle isotopes in a short decay chain to stable 209Bi, and as such can be described as an alpha particle nanogenerator. This article reviews the literature pertaining to the research, development, and utilization of targeted 225Ac to potently and specifically affect cancer. © 2008 Elsevier B.V. All rights reserved.
Keywords: clinical trial; review; nonhuman; clinical trials as topic; ibritumomab tiuxetan; cd8+ t lymphocyte; isotopes; animals; unindexed drug; radiation; monoclonal antibody; monoclonal antibody j591; iodine 131; drug distribution; tissue distribution; dosimetry; radioactivity; energy transfer; malignant neoplastic disease; targeted therapy; drug metabolism; radiometry; drug half life; trastuzumab; major histocompatibility complex; radioimmunotherapy; tositumomab i 131; radioisotopes; captopril; acetic acid; chelate; 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetraacetic acid; liposome; tetramer; biotin; tumor cells; acetic acid derivative; radiobiology; alpha radiation; pentetic acid; alpha particles; 225ac; carbon nanotube; actinium; yttrium 90; actinium 225; linear energy transfer; particle radiation; astatine 211; bismuth 213; actinium-225; alpha particle-emitter; dota; nano-device; actinides; charged particles; energy storage; stabilizers (agents); (pl) properties; alpha particle therapy; alpha tracks; cell diameters; cytotoxic agents; high-linear energy transfer (let); single cells; 2 ethyl 5,7 dimethyl 3 [4 [2 (2h tetrazol 5 yl)phenyl]benzyl]imidazo[4,5 b]pyridine; cesium 132; cesium ion; edetic acid; ethylenediamine tetrakis(methylenephosphonic acid); francium; francium 221; succimer; unithiol; radionuclide generators
Journal Title: Advanced Drug Delivery Reviews
Volume: 60
Issue: 12
ISSN: 0169-409X
Publisher: Elsevier Science, Inc.  
Date Published: 2008-09-15
Start Page: 1371
End Page: 1382
Language: English
DOI: 10.1016/j.addr.2008.04.009
PUBMED: 18514364
PROVIDER: scopus
PMCID: PMC3630456
DOI/URL:
Notes: --- - "Cited By (since 1996): 18" - "Export Date: 17 November 2011" - "CODEN: ADDRE" - "Source: Scopus"
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  1. Michael R Mcdevitt
    135 Mcdevitt
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