Radiogenomic evaluation of lung cancer — Are there imaging characteristics associated with lung adenocarcinomas harboring BRAF mutations? Journal Article


Authors: Halpenny, D. F.; Plodkowski, A.; Riely, G.; Zheng, J.; Litvak, A.; Moscowitz, C.; Ginsberg, M. S.
Article Title: Radiogenomic evaluation of lung cancer — Are there imaging characteristics associated with lung adenocarcinomas harboring BRAF mutations?
Abstract: Introduction We studied computed tomography (CT) features associated with BRAF mutated lung cancer. Materials and methods CT features of BRAF mutated lung cancers were compared to stage matched lesions without BRAF mutation. Results 47 (25%) patients with BRAF mutation and 141 (75%) without BRAF mutation were included. BRAF lesions were most frequently solid 37 (84%), spiculated 22 (50%), and peripheral 37 (84%). No feature of the primary tumor was significantly different between BRAF and non-BRAF groups. BRAF patients were more likely than KRAS patients to have pleural metastases [5 (11%) vs 0 (0%), p = 0.045]. Conclusion No feature of the primary tumor differentiates BRAF lesions from non-BRAF lesions. © 2016
Keywords: lung cancer; computerized tomography; tomography; tumors; lung carcinoma; biological organs; diseases; computed tomography; braf mutation; imaging characteristics; radiogenomics
Journal Title: Clinical Imaging
Volume: 42
ISSN: 0899-7071
Publisher: Elsevier Inc.  
Date Published: 2017-03-01
Start Page: 147
End Page: 151
Language: English
DOI: 10.1016/j.clinimag.2016.11.015
PROVIDER: scopus
PUBMED: 28012356
PMCID: PMC5361574
DOI/URL:
Notes: Article -- Export Date: 2 February 2017 -- Source: Scopus
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MSK Authors
  1. Junting Zheng
    130 Zheng
  2. Michelle S Ginsberg
    158 Ginsberg
  3. Chaya S. Moskowitz
    172 Moskowitz
  4. Gregory J Riely
    344 Riely
  5. Anna Maria Litvak
    25 Litvak