CT features of ovarian tumors: Defning key differences between serous borderline tumors and low-grade serous carcinomas Journal Article

  

Authors:	Nougaret, S.; Lakhman, Y.; Molinari, N.; Feier, D.; Scelzo, C.; Vargas, H. A.; Sosa, R. E.; Hricak, H.; Soslow, R. A.; Grisham, R. N.; Sala, E.
Article Title:	CT features of ovarian tumors: Defning key differences between serous borderline tumors and low-grade serous carcinomas
Abstract:	OBJECTIVE. The objective of our study was to investigate whether the CT features of serous borderline tumors (SBTs) differ from those of low-grade serous carcinomas (LGSCs) and to evaluate if mutation status is associated with distinct CT phenotypes. MATERIALS AND METHODS. This retrospective study included 59 women, 37 with SBT and 22 with LGSC, who underwent CT before primary surgical resection. Thirty of 59 patients were genetically profled. Two radiologists (readers 1 and 2) independently and retrospectively reviewed CT examinations for qualitative features and quantifed total tumor volumes (TTVs), solid tumor volumes (STVs), and solid proportion of ovarian masses. Univariate and multivariate associations of the CT features with histopathologic diagnoses and mutations were evaluated, and interreader agreement was determined. RESULTS. At multivariate analysis, the presence of bilateral ovarian masses (p = 0.03), the presence of peritoneal disease (PD) (p = 0.002), and higher STV of ovarian masses (p = 0.002) were associated with LGSC. The presence of nodular PD pattern (p < 0.001 each reader) and the presence of PD calcifcations (reader 1, p = 0.02; reader 2, p = 0.003) were associated with invasive peritoneal lesions (i.e., LGSC). The presence of bilateral ovarian masses (p = 0.04 each reader), PD (reader 1, p = 0.01; reader 2, p = 0.004), and higher STV (p = 0.03 for each reader) were associated with the absence of BRAF mutation (i.e., wild type [wt]-BRAF). CONCLUSION. The CT features of LGSCs were distinct from those of SBTs. The CT manifestations of LGSC and the wt-BRAF phenotype were similar. © American Roentgen Ray Society.
Keywords:	adult; human tissue; aged; middle aged; cancer surgery; major clinical study; histopathology; diagnostic accuracy; sensitivity and specificity; genetic analysis; phenotype; disease association; computer assisted tomography; tumor volume; tumor differentiation; cohort analysis; mutational analysis; retrospective study; ovary tumor; dna fingerprinting; peritoneum metastasis; b raf kinase; ct; predictive value; multidetector computed tomography; braf mutation; qualitative analysis; braf gene; diagnostic test accuracy study; serous borderline tumor; low grade serous carcinoma; human; female; priority journal; article; radiogenomics; solid malignant neoplasm; low-grade serous ovarian carcinoma
Journal Title:	American Journal of Roentgenology
Volume:	210
Issue:	4
ISSN:	0361-803X
Publisher:	American Roentgen Ray Society
Date Published:	2018-04-01
Start Page:	918
End Page:	926
Language:	English
DOI:	10.2214/ajr.17.18254
PROVIDER:	scopus
PUBMED:	29489407
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044524123&doi=10.2214%2fAJR.17.18254&partnerID=40&md5=d9bef2f69d8cb632602ad85f195a9500
Notes:	Yuliya Lakhman's first name is misspelled on the original publication -- Article -- Export Date: 1 May 2018 -- Source: Scopus