CT features of HER2-mutant lung adenocarcinomas Journal Article


Authors: Sawan, P.; Plodkowski, A. J.; Li, A. E.; Li, B. T.; Drilon, A.; Capanu, M.; Ginsberg, M. S.
Article Title: CT features of HER2-mutant lung adenocarcinomas
Abstract: Objectives: To describe the radiological phenotype of HER2-mutant lung cancers on CT at presentation. Methods: Eligible patients with lung adenocarcinomas with HER2 mutations were stage-matched with two control groups (EGFR- and KRAS-mutant groups). Evaluated CT features of the primary tumor included size, location, consistency, contour, presence of pleural tags and pleural retractions. Presence of pleural effusions, lung metastases, adenopathy, chest wall invasion, and were also recorded. Wilcoxon rank-sum and Fisher's exact tests were used to compare continuous and categorical features, respectively. Results: One hundred and fifty-four patients were identified: 50 (33%) harbored HER2 mutations, 56 (36%) harbored KRAS mutations, and 48 (31%) harbored EGFR mutations. Compared with KRAS, HER2 tumors presented as smaller lesions (2.3 cm versus 2.9 cm, p = 0.005 for length; 1.6 cm versus 2.1 cm, p = 0.002 for width) with the presence of pleural tags (74% vs. 52%, p = 0.03), pleural retractions (58% vs. 39%, p = 0.006), ipsilateral hilar (36% vs. 16%, p = 0.03) and scalene/supraclavicular N3 adenopathy (24% vs. 7%, p = 0.03). Compared with EGFR, pleural retractions were more prevalent among the HER2 tumors (58% vs. 37%, p = 0.05). Conclusions: Lung adenocarcinomas with HER2 gene mutation exhibit an aggressive behavior manifesting by higher incidence of local invasion, compared to KRAS and EGFR mutant controls, and a nodal metastatic spread compared to KRAS-mutant control. This is the first radiogenomics study of HER2 mutations in lung cancer. © 2018 Elsevier Inc.
Keywords: lung adenocarcinoma; tumors; egfr; kras; biological organs; diseases; her2; multidetector computed tomography; radiogenomics
Journal Title: Clinical Imaging
Volume: 51
ISSN: 0899-7071
Publisher: Elsevier Inc.  
Date Published: 2018-09-01
Start Page: 279
End Page: 283
Language: English
DOI: 10.1016/j.clinimag.2018.05.028
PROVIDER: scopus
PUBMED: 29906786
DOI/URL:
Notes: Review -- Export Date: 2 July 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Michelle S Ginsberg
    154 Ginsberg
  2. Marinela Capanu
    189 Capanu
  3. Alexander Edward Drilon
    132 Drilon
  4. Bob Tingkan Li
    57 Li
  5. Angela En Hui Li
    2 Li
  6. Peter Sawan
    5 Sawan