From genotype to phenotype: Are there imaging characteristics associated with lung adenocarcinomas harboring RET and ROS1 rearrangements? Journal Article

Authors: Plodkowski, A. J.; Drilon, A.; Halpenny, D. F.; O'Driscoll, D.; Blair, D.; Litvak, A. M.; Zheng, J.; Moskowitz, C. S.; Ginsberg, M. S.
Article Title: From genotype to phenotype: Are there imaging characteristics associated with lung adenocarcinomas harboring RET and ROS1 rearrangements?
Abstract: INTRODUCTION: Recurrent gene rearrangements are important drivers of oncogenesis in non-small cell lung cancers. RET and ROS1 rearrangements are each found in 1-2% of lung adenocarcinomas and represent distinct molecular subsets. This study assessed the computed tomography (CT) imaging features of patients with RET- and ROS1-rearranged lung cancers. METHODS: Eligible patients included pathologically-confirmed lung adenocarcinomas of any stage with a RET or ROS1 rearrangement via fluorescence in-situ hybridization or next-generation sequencing, and available pre-treatment baseline imaging for review. A cohort of EGFR-mutant lung cancers was identified as a control group. CT features assessed included location, consistency, contour, presence of cavitation, and calcification of the primary tumor. Presence of an effusion, lung metastases, adenopathy and extrathoracic disease were recorded. The Wilcoxon rank-sum/Kruskal-Wallis and Fisher's exact tests were used to compare features between groups. RESULTS: 73 patients with lung adenocarcinomas were identified: 17 (23%) with ROS1 fusions, 25 (34%) with RET fusions and 31 (43%) with EGFR mutations. ROS1-rearranged lung cancers were more likely to present as peripheral tumors in comparison to EGFR-mutant lung cancers (32% vs. 65%, p=0.04). RET-rearranged lung cancers did not significantly differ from EGFR-mutant lung cancers radiographically. The consistency of the primary lesion for RET and ROS fusions and EGFR mutations were most frequently solid and spiculated. CONCLUSIONS: Lung adenocarcinomas with RET and ROS1 fusions share many radiographic features and those with ROS1 fusions are more likely to present as peripheral lesions in comparison to EGFR-mutant lung cancers. © 2015 Elsevier Ireland Ltd. All rights reserved.
Keywords: lung adenocarcinoma; computed tomography; egfr mutation; ros1 rearrangement; ret rearrangement
Journal Title: Lung Cancer
Volume: 90
Issue: 2
ISSN: 0169-5002
Publisher: Elsevier Ireland Ltd.  
Date Published: 2015-11-01
Start Page: 321
End Page: 325
Language: English
DOI: 10.1016/j.lungcan.2015.09.018
PROVIDER: scopus
PUBMED: 26424208
PMCID: PMC4907505
Notes: Article -- Export Date: 3 February 2016 -- Source: Scopus
Citation Impact
MSK Authors
  1. Junting Zheng
    156 Zheng
  2. Michelle S Ginsberg
    179 Ginsberg
  3. Chaya S. Moskowitz
    203 Moskowitz
  4. Alexander Edward Drilon
    275 Drilon
  5. Anna Maria Litvak
    27 Litvak
  6. Donald Joseph Blair
    2 Blair