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Genome editing technologies: Defining a path to clinic

Journal Article

Corrigan-Curay, J.; O'Reilly, M.; Kohn, D. B.; Cannon, P. M.; Bao, G.; Bushman, F. D.; Carroll, D.; Cathomen, T.; Joung, J. K.; Roth, D.; more...
Molecular Therapy (2015)

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Biological properties of ligand-dependent activation of the MET receptor kinase in acute myeloid leukemia

Journal Article

Mcgee, S. F.; Kornblau, S. M.; Qiu, Y.; Look, A. T.; Zhang, N.; Yoo, S. Y.; Coombes, K. R.; Kentsis, A.
Leukemia (2015)

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Smoldering multiple myeloma

Journal Article

Rajkumar, S. V.; Landgren, O.; Mateos, M. V.
Blood (2015)

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A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer

Journal Article

Koneru, M.; O'cearbhaill, R.; Pendharkar, S.; Spriggs, D. R.; Brentjens, R. J.
Journal of Translational Medicine (2015)

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Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94

Journal Article

Patel, H. J.; Patel, P. D.; Ochiana, S. O.; Yan, P.; Sun, W.; Patel, M. R.; Shah, S. K.; Tramentozzi, E.; Brooks, J.; Bolaender, A.; more...
Journal of Medicinal Chemistry (2015)

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Central role of ULK1 in type I interferon signaling

Journal Article

Saleiro, D.; Mehrotra, S.; Kroczynska, B.; Beauchamp, E. M.; Lisowski, P.; Majchrzak-Kita, B.; Bhagat, T. D.; Stein, B. L.; McMahon, B.; Altman, J. K.; more...
Cell Reports (2015)

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T-cell depleted allogeneic hematopoietic stem cell transplantation for patients with relapsed, high-risk multiple myeloma permits long-lasting remissions in the absence of graft-versus-host disease

Meeting Abstract

Koehne, G.; Devlin, S.; Landau, H.; Hassoun, H.; Lesokhin, A.; Lendvai, N.; Chung, D.; Giralt, S.
Bone Marrow Transplantation (2015)

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Two chemotherapy-based conditioning regimens compared to TBI-based conditioning secure consistent engraftment of T-cell depleted allogeneic HSCT, similarly low incidences of GVHD and favorable rates of disease-free survival (DFS)

Meeting Abstract

Koehne, G.; Boulad, F.; Barker, J.; Castro-Malaspina, H.; Curran, K.; Giralt, S.; Hasan, A.; Heller, G.; Hsu, K.; Jakubowski, A.; more...
Bone Marrow Transplantation (2015)

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On being less tolerant: Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation

Journal Article

Lesokhin, A. M.; Callahan, M. K.; Postow, M. A.; Wolchok, J. D.
Science Translational Medicine (2015)

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New cell sources for T cell engineering and adoptive immunotherapy

Journal Article

Themeli, M.; Rivière, I.; Sadelain, M.
Cell Stem Cell (2015)

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