New cell sources for T cell engineering and adoptive immunotherapy Journal Article


Authors: Themeli, M.; Rivière, I.; Sadelain, M.
Article Title: New cell sources for T cell engineering and adoptive immunotherapy
Abstract: The promising clinical results obtained with engineered T cells, including chimeric antigen receptor (CAR) therapy, call for further advancements to facilitate and broaden their applicability. One potentially beneficial innovation is to exploit new T cell sources that reduce the need for autologous cell manufacturing and enable cell transfer across histocompatibility barriers. Here we review emerging T cell engineering approaches that utilize alternative T cell sources, which include virus-specific or T cell receptor-less allogeneic T cells, expanded lymphoid progenitors, and induced pluripotent stem cell (iPSC)-derived T lymphocytes. The latter offer the prospect for true off-the-shelf, genetically enhanced, histocompatible cell therapy products. © 2015 Elsevier Inc. All rights reserved.
Keywords: allogeneic stem cell transplantation; review; nonhuman; t lymphocyte; cancer immunotherapy; embryonic stem cell; autologous stem cell transplantation; t lymphocyte receptor; dna modification; antigen specificity; antigen recognition; graft versus host reaction; chimeric antigen receptor; adoptive transfer; pluripotent stem cell; hematopoietic stem cell; cross reaction; lymphoid progenitor cell; freeze thawing; adoptive immunotherapy; bioreactor; lymphocyte antigen receptor; lymphocyte function; virus vector; histocompatibility; tumor escape; lymphocyte transfer; cell engineering; human; priority journal
Journal Title: Cell Stem Cell
Volume: 16
Issue: 4
ISSN: 1934-5909
Publisher: Cell Press  
Date Published: 2015-04-02
Start Page: 357
End Page: 366
Language: English
DOI: 10.1016/j.stem.2015.03.011
PROVIDER: scopus
PUBMED: 25842976
PMCID: PMC5611846
DOI/URL:
Notes: Export Date: 4 May 2015 -- Source: Scopus
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MSK Authors
  1. Michel W J Sadelain
    462 Sadelain
  2. Isabelle C Riviere
    168 Riviere
  3. Maria Themeli
    11 Themeli