New cell sources for T cell engineering and adoptive immunotherapy Journal Article
| Authors: | Themeli, M.; Rivière, I.; Sadelain, M. |
| Article Title: | New cell sources for T cell engineering and adoptive immunotherapy |
| Abstract: | The promising clinical results obtained with engineered T cells, including chimeric antigen receptor (CAR) therapy, call for further advancements to facilitate and broaden their applicability. One potentially beneficial innovation is to exploit new T cell sources that reduce the need for autologous cell manufacturing and enable cell transfer across histocompatibility barriers. Here we review emerging T cell engineering approaches that utilize alternative T cell sources, which include virus-specific or T cell receptor-less allogeneic T cells, expanded lymphoid progenitors, and induced pluripotent stem cell (iPSC)-derived T lymphocytes. The latter offer the prospect for true off-the-shelf, genetically enhanced, histocompatible cell therapy products. © 2015 Elsevier Inc. All rights reserved. |
| Keywords: | allogeneic stem cell transplantation; review; nonhuman; t lymphocyte; cancer immunotherapy; embryonic stem cell; autologous stem cell transplantation; t lymphocyte receptor; dna modification; antigen specificity; antigen recognition; graft versus host reaction; chimeric antigen receptor; adoptive transfer; pluripotent stem cell; hematopoietic stem cell; cross reaction; lymphoid progenitor cell; freeze thawing; adoptive immunotherapy; bioreactor; lymphocyte antigen receptor; lymphocyte function; virus vector; histocompatibility; tumor escape; lymphocyte transfer; cell engineering; human; priority journal |
| Journal Title: | Cell Stem Cell |
| Volume: | 16 |
| Issue: | 4 |
| ISSN: | 1934-5909 |
| Publisher: | Cell Press |
| Date Published: | 2015-04-02 |
| Start Page: | 357 |
| End Page: | 366 |
| Language: | English |
| DOI: | 10.1016/j.stem.2015.03.011 |
| PROVIDER: | scopus |
| PUBMED: | 25842976 |
| PMCID: | PMC5611846 |
| DOI/URL: | |
| Notes: | Export Date: 4 May 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work