Advances in immunotherapy of hematologic malignancies: Cellular and humoral approaches Journal Article
| Authors: | Jurcic, J. G.; Cathcart, K.; Pinilla-Ibarz, J.; Scheinberg, D. A. |
| Article Title: | Advances in immunotherapy of hematologic malignancies: Cellular and humoral approaches |
| Abstract: | Monoclonal antibodies have become an important modality for cancer therapy. Genetically engineered chimeric and humanized antibodies have demonstrated activity against overt lymphoma and leukemia, as well as minimal residual disease. Radioimmunotherapy in both nonmyeloablative and myeloablative regimens has produced significant responses and also minimized radiation exposure to normal tissues. Targeted α-particle therapy offers the possibility of selective tumor cell kill. Antibody-drug conjugates have produced remissions in acute leukemia. Many proteins potentially act as leukemia or lymphoma-specific antigens for major histocompatibility complex- restricted T cell cytotoxicity. These include the idiotype proteins, breakpoint cluster region (bcr)-abl and other fusion oncoproteins, myeloid- specific differentiation antigens and minor histocompatibility antigens. Clinical trials exploiting the new understanding of the T cell immunology are underway. (C) 2000 Lippincott Williams and Wilkins, Inc. |
| Keywords: | human tissue; unclassified drug; human cell; clinical trial; review; salvage therapy; rituximab; cancer immunotherapy; antineoplastic combined chemotherapy protocols; neoplasm proteins; chronic myeloid leukemia; antigen presentation; dendritic cells; antibodies, monoclonal; nonhodgkin lymphoma; hematologic neoplasms; immunotherapy; iodine 131; cancer vaccine; genetic engineering; cancer vaccines; antigen specificity; minimal residual disease; lymphoma, non-hodgkin; cytotoxic t lymphocyte; phase 1 clinical trial; radioimmunotherapy; antibodies, neoplasm; drug conjugation; clinical trials; antibody formation; immunity, cellular; immunoconjugates; yttrium 90; actinium 225; astatine 211; bismuth 213; bismuth 212; rhenium 188; immunoglobulin idiotypes; rhenium 186; copper 67; humans; human; priority journal |
| Journal Title: | Current Opinion in Hematology |
| Volume: | 7 |
| Issue: | 4 |
| ISSN: | 1065-6251 |
| Publisher: | Lippincott Williams & Wilkins, Ltd. |
| Date Published: | 2000-07-01 |
| Start Page: | 247 |
| End Page: | 254 |
| Language: | English |
| DOI: | 10.1097/00062752-200007000-00008 |
| PUBMED: | 10882181 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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14Cathcart -
134Jurcic -
499Scheinberg -
30Pinilla
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