Immunotherapy for acute myeloid leukemia Journal Article
| Author: | Jurcic, J. G. |
| Article Title: | Immunotherapy for acute myeloid leukemia |
| Abstract: | Immunotherapeutic strategies have become part of standard cancer treatment. Chimeric and humanized antibodies have demonstrated activity against a variety of tumors. Although the humanized anti-CD33 antibody HuM195 has only modest activity against overt acute myeloid leukemia (AML), it can eliminate minimal residual disease in acute promyelocytic leukemia. High-dose radioimmunotherapy with β-particle-emitting isotopes targeting CD33, CD45, and CD66 can potentially allow intensification of antileukemic therapy before hematopoietic stem cell transplantation. Conversely, α-particle immunotherapy with isotopes such as bismuth-213 or actinium-225 offers the possibility of selective tumor cell kill while sparing surrounding normal tissues. Targeted chemotherapy with the anti-CD33-calicheamicin construct gemtuzumab ozogamicin has produced remissions in relapsed AML and appears promising when used in combination with standard chemotherapy for newly diagnosed AML. T-cell recognition of peptide antigens presented on the cell surface in combination with major histocompatibility complex antigen provides another potentially promising approach for the treatment of AML. Copyright © 2005 by Current Science Inc. |
| Keywords: | acute granulocytic leukemia; busulfan; clinical trial; review; dose response; nonhuman; liver dysfunction; drug targeting; cytarabine; t lymphocyte; t-lymphocytes; unindexed drug; cancer immunotherapy; apoptosis; liver toxicity; bone marrow suppression; etoposide; recurrence; cyclophosphamide; hematopoietic stem cell transplantation; antineoplastic activity; arsenic trioxide; t lymphocyte receptor beta chain; antibodies, monoclonal; immunotherapy; iodine 131; drug mechanism; mitoxantrone; daunorubicin; promyelocytic leukemia; tumor cell; remission induction; cell adhesion molecules; hyperbilirubinemia; idarubicin; antigens, cd; radioimmunotherapy; radioisotopes; retinoic acid; cd45 antigen; diphtheria toxin; cd33 antigen; gemtuzumab ozogamicin; electron; biotin; antigens, differentiation, myelomonocytic; t lymphocyte receptor alpha chain; cell surface; saponin; antigens, cd45; alpha radiation; aminoglycosides; immunotoxins; bismuth; actinium; yttrium 90; astatine 211; bismuth 213; monoclonal antibody m 195; liver vein obstruction; rhenium 188; leukemia, myelocytic, acute; ricin; basiliximab; bacterial toxin; gelonin; pokeweed antivirus protein |
| Journal Title: | Current Oncology Reports |
| Volume: | 7 |
| Issue: | 5 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2005-09-01 |
| Start Page: | 339 |
| End Page: | 346 |
| Language: | English |
| PUBMED: | 16091194 |
| PROVIDER: | scopus |
| DOI: | 10.1007/s11912-005-0060-7 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 12" - "Export Date: 24 October 2012" - "CODEN: CORUA" - "Source: Scopus" |
