Antibody therapy in acute myeloid leukemia: Current status and future directions Journal Article
| Authors: | Burke, J. M. ; Jurcic, J. G. |
| Article Title: | Antibody therapy in acute myeloid leukemia: Current status and future directions |
| Abstract: | Monoclonal antibodies have become an important modality for cancer therapy. The genetically engineered, humanized anti-CD33 antibody HuM195 has demonstrated modest activity against overt relapsed acute myeloid leukemia (AML) and more substantial activity against minimal residual disease in acute promyelocytic leukemia. Radioimmunotherapy with β-particle-emitting isotopes has eliminated large leukemic burdens while minimizing radiation exposure to normal tissues in both nonmyeloablative and myeloablative regimens. Targeted β-particle immunotherapy with agents such as bismuth 213-labeled HuM195 offers the possibility of a more selective tumor cell kill with less damage to surrounding normal cells. Directed chemotherapy using the anti-CD33-calicheamicin conjugate gemtuzumab ozogamicin (Mylotarg®) has produced remissions in patients with relapsed AML. |
| Keywords: | controlled study; unclassified drug; acute granulocytic leukemia; busulfan; drug activity; cancer recurrence; drug targeting; cytarabine; interleukin 2; nausea; cyclophosphamide; drug selectivity; radiation exposure; monoclonal antibody; fever; hypotension; antibodies, monoclonal; rigor; iodine 131; genetic engineering; isotope labeling; minimal residual disease; cell damage; promyelocytic leukemia; idarubicin; radioimmunotherapy; retinoic acid; isotope; diphtheria toxin; gemtuzumab ozogamicin; leukemia remission; pseudomonas exotoxin; saponin; antibody conjugate; bismuth; actinium; yttrium 90; bismuth 213; acute myeloid leukemia; monoclonal antibody m 195; rhenium 188; leukemia, myelocytic, acute; calicheamicin; ricin; gelonin; pokeweed antivirus protein; antibody-dependent cell cytotoxicity; humans; human; article; anti-cd 33 monoclonal antibody; anti-cd45 monoclonal antibody; monoclonal antibody bc8; monoclonal antibody bw 250 183; monoclonal antibody p67; electron radiation |
| Journal Title: | Clinical Lymphoma |
| Volume: | 2 |
| Issue: | Suppl.1 |
| ISSN: | 1526-9655 |
| Publisher: | Cancer Information Group |
| Date Published: | 2002-03-01 |
| Start Page: | S12 |
| End Page: | S18 |
| Language: | English |
| PUBMED: | 11970765 |
| PROVIDER: | scopus |
| DOI: | 10.3816/CLM.2002.s.003 |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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