Novel targeted and immunotherapeutic strategies in chronic myeloid leukemia Journal Article
| Authors: | Schwartz, J.; Pinilla-Ibarz, J.; Yuan, R. R.; Scheinberg, D. A. |
| Article Title: | Novel targeted and immunotherapeutic strategies in chronic myeloid leukemia |
| Abstract: | The advanced understanding of the molecular biology and immunology of chronic myeloid leukemia (CML) has led to novel therapeutic strategies unique to this disease. CML responds to immune-mediated therapies, including stem cell transplantation, donor lymphocyte infusion (DLI), and interferon alfa. T cells and other immune effectors are implicated in the mechanisms of action of these immune therapies. Recently, clinical observations supported by laboratory data have demonstrated the presence of CML-specific T cells in patients. Several proteins may potentially act as leukemia-specific antigens for major histocompatibility complex (MHC)-restricted cytotoxicity in CML, and active specific therapies (vaccines) are in development. Antigens under investigation include bcr-abl, PR1, Wilms tumor protein (WT1), minor histocompatibility antigens (mH), CML-66, CML-28, and survivin. Other strategies target vascular endothelial growth factor (VEGF) and heat shock protein 90 (Hsp90) inhibitors or make use of CML-derived dendritic cells (DC). Copyright 2003, Elsevier Science (USA). All rights reserved. |
| Keywords: | vasculotropin; unclassified drug; clinical trial; review; drug efficacy; drug safety; antineoplastic agents; alpha interferon; t lymphocyte; cancer immunotherapy; dendritic cell; stem cell transplantation; cytotoxicity; chronic myeloid leukemia; survivin; tumor antigen; dendritic cells; immunotherapy; antigens, neoplasm; cancer vaccine; tumor protein; heat shock protein 90; effector cell; bcr abl protein; wt1 protein; lymphocyte; immunocompetent cell; major histocompatibility complex restriction; delayed hypersensitivity; pr1 antigen; minor histocompatibility antigen; leukemia, myeloid, chronic; humans; human; priority journal; cml 28 antigen; cml 66 antigen |
| Journal Title: | Seminars in Hematology |
| Volume: | 40 |
| Issue: | 1 |
| ISSN: | 0037-1963 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2003-01-01 |
| Start Page: | 87 |
| End Page: | 96 |
| Language: | English |
| DOI: | 10.1016/s0037-1963(03)70046-8 |
| PUBMED: | 12563615 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
5Schwartz -
4
Yuan -
499Scheinberg -
30
Pinilla
Related MSK Work