CML vaccines as a paradigm of the specific immunotherapy of cancer Journal Article

  


Authors: Pinilla-Ibarz, J.; Cathcart, K.; Scheinberg, D. A.
Article Title: CML vaccines as a paradigm of the specific immunotherapy of cancer
Abstract: T cells are implicated in the effective control of chronic myeloid leukemia (CML). Recently, several clinical observations supported by laboratory data, indicate the presence of CML-specific T cells. Many proteins potentially act as leukemia-specific antigens for MHC-restricted cytotoxicity in CML. These include the bcr-abl fusion protein, myeloid-specific differentiation antigens and minor histocompatibility antigens. There is recent evidence to suggest that bcr-abl junctional peptides are capable of eliciting both CD4 and CD8 responses in normal healthy donors and in patients with CML. Moreover, T cell lines can be generated that react with autologous or HLA-matched fresh CML cells, suggesting that the bcr-abl fusion protein can be processed and expressed in the MHC cell surface molecules. Clinical trials exploiting the new understanding of the immunology of CML are underway. (C) 2000 Harcourt Publishers Ltd.
Keywords: clinical trial; review; cd8 antigen; t lymphocyte; cancer immunotherapy; dendritic cell; chronic myeloid leukemia; antigens, neoplasm; cancer vaccine; cancer vaccines; t-lymphocytes, cytotoxic; bcr abl protein; cd4 antigen; immunotherapy, adoptive; hla antigen; fusion proteins, bcr-abl; leukemia antigen; major histocompatibility antigen; leukemia, myeloid, chronic; human; priority journal
Journal Title: Blood Reviews
Volume: 14
Issue: 2
ISSN: 0268-960X
Publisher: Churchill Livingstone  
Date Published: 2000-06-01
Start Page: 111
End Page: 120
Language: English
DOI: 10.1054/blre.2000.0127
PUBMED: 11012250
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0033866145&partnerID=40&md5=be93c56a505de99a7ce4bd051029a5bd
Notes: Export Date: 18 November 2015 -- Source: Scopus
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MSK Authors
  1. Kathleen N S Cathcart
    14 Cathcart
  2. David Scheinberg
    499 Scheinberg
  3. Javier Pinilla
    30 Pinilla
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