On being less tolerant: Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation Journal Article
| Authors: | Lesokhin, A. M.; Callahan, M. K.; Postow, M. A.; Wolchok, J. D. |
| Article Title: | On being less tolerant: Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation |
| Abstract: | The recent approvals of two drugs that block the function of the immune checkpoint programmed cell death 1 (PD-1) have firmly planted tumor immunotherapy in the mainstream of clinical oncology. We provide a historical and immunologic context for these recent advances and discuss translational studies that provide insight into the efficacy of cancer immunotherapy at the individual patient level. © 2015, AAAS. All rights reserved. |
| Keywords: | signal transduction; unclassified drug; review; hepatitis; cisplatin; diarrhea; drug efficacy; drug safety; nonhuman; drug targeting; paclitaxel; colorectal cancer; carboplatin; dacarbazine; ipilimumab; ticilimumab; unindexed drug; cancer immunotherapy; melanoma; neuropathy; kidney carcinoma; monoclonal antibody; arthralgia; pneumonia; prostate cancer; pruritus; rash; t lymphocyte receptor; immunological tolerance; hematologic malignancy; drug mechanism; pancreatitis; drug response; colitis; cell cycle checkpoint; hypothyroidism; peptide vaccine; immunosurveillance; cell interaction; drug tolerance; cytopenia; t lymphocyte activation; tgn 1412; uveitis; non small cell lung cancer; myopathy; adrenal insufficiency; randomized controlled trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); phase 1 clinical trial (topic); hypophysitis; vitiligo; conjunctivitis; thyroiditis; cp 870893; nephritis; nivolumab; amp 224; mpdl 3280a; pidilizumab; pf 05082566; trx 518; urelumab; human; priority journal; dacetuzumab; pembrolizumab; durvalumab; bms 956559; bms 986016; imp 321; med i6469; mga 271; mk 4166; moxr 0916; msb 0010718 c; varlilumab |
| Journal Title: | Science Translational Medicine |
| Volume: | 7 |
| Issue: | 280 |
| ISSN: | 1946-6234 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2015-03-25 |
| Start Page: | 280sr1 |
| Language: | English |
| DOI: | 10.1126/scitranslmed.3010274 |
| PROVIDER: | scopus |
| PUBMED: | 25810313 |
| DOI/URL: | |
| Notes: | Export Date: 4 May 2015 -- Source: Scopus |
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