Genomic profile, smoking, and response to anti-PD-1 therapy in non-small cell lung carcinoma Journal Article


Authors: Hellmann, M.; Rizvi, N.; Wolchok, J. D.; Chan, T. A.
Article Title: Genomic profile, smoking, and response to anti-PD-1 therapy in non-small cell lung carcinoma
Abstract: The recent successes of immune checkpoint therapies have established a new era for the treatment of patients with cancer, yet the predictors of response remain largely undetermined. We recently demonstrated that the genomic landscape of lung cancers substantially influences the response to programmed cell death 1 receptor (PD-1) blockade, providing new insights into the molecular determinants of the response to immunotherapy.
Keywords: mutation; immunotherapy; lung; mutations; landscape; blockade; cancer
Journal Title: Molecular & Cellular Oncology
Volume: 3
Issue: 1
ISSN: 2372-3556
Publisher: Taylor & Francis Group  
Date Published: 2016-01-01
Start Page: e1048929
Language: English
ACCESSION: WOS:000385245700042
DOI: 10.1080/23723556.2015.1048929
PROVIDER: wos
PMCID: PMC4845184
PUBMED: 27308563
Notes: Article -- Source: Wos
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  1. Timothy Chan
    317 Chan
  2. Jedd D Wolchok
    905 Wolchok
  3. Matthew David Hellmann
    412 Hellmann