Engaging the vascular component of the tumor response Journal Article
| Authors: | Fuks, Z.; Kolesnick, R. |
| Article Title: | Engaging the vascular component of the tumor response |
| Abstract: | Recent research has shed new light on the critical role of tissue microvasculature in regulating the tumor response to radiation and drugs. In this issue of Cancer Cell, Moeller et al. (2005) demonstrate that HIF-1 activation during the course of fractionated radiotherapy initiates pleiotropic adaptive responses in both tumor cells and the microvascular network, radiosensitizing tumor cells but concomitantly conferring tumor radioresistance due to protection of the microvascular endothelium. HIF-1 thus serves as a legitimate target for differential modulation of tissue response to radiation. Copyright © 2005 Elsevier Inc. |
| Keywords: | vasculotropin; promoter region; dna-binding proteins; pathogenesis; nonhuman; cancer radiotherapy; neoplasms; cell death; cell survival; gene targeting; genetic transcription; angiogenesis; radiation injury; neovascularization, pathologic; oncogene h ras; radiation exposure; transcription factors; nuclear proteins; hypoxia; endothelium cell; molecular mechanics; endothelium, vascular; radiation dose fractionation; tumor cell; reactive oxygen metabolite; short survey; radiosensitivity; gene control; gene inactivation; tumor growth; tumor vascularization; cell interaction; hypoxia-inducible factor 1, alpha subunit; clonogenesis; ceramide; reoxygenation; radiation tolerance; sphingomyelin; hypoxia inducible factor 1; cross tolerance; hypoxia-inducible factor 1; capillaries |
| Journal Title: | Cancer Cell |
| Volume: | 8 |
| Issue: | 2 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2005-08-01 |
| Start Page: | 89 |
| End Page: | 91 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2005.07.014 |
| PUBMED: | 16098459 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 71" - "Export Date: 24 October 2012" - "CODEN: CCAEC" - "Source: Scopus" |
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