Using CRISPR/Cas to study gene function and model disease in vivo Journal Article
| Authors: | Tschaharganeh, D. F.; Lowe, S. W.; Garippa, R. J.; Livshits, G. |
| Article Title: | Using CRISPR/Cas to study gene function and model disease in vivo |
| Abstract: | The recent discovery of the CRISPR/Cas system and repurposing of this technology to edit a variety of different genomes have revolutionized an array of scientific fields, from genetics and translational research, to agriculture and bioproduction. In particular, the prospect of rapid and precise genome editing in laboratory animals by CRISPR/Cas has generated an immense interest in the scientific community. Here we review current in vivo applications of CRISPR/Cas and how this technology can improve our knowledge of gene function and our understanding of biological processes in animal models. © 2016 Federation of European Biochemical Societies |
| Keywords: | mouse models; cancer; genome editing; crispr/cas9; disease models |
| Journal Title: | FEBS Journal |
| Volume: | 283 |
| Issue: | 17 |
| ISSN: | 1742-464X |
| Publisher: | Blackwell Publishing |
| Date Published: | 2016-09-01 |
| Start Page: | 3194 |
| End Page: | 3203 |
| Language: | English |
| DOI: | 10.1111/febs.13750 |
| PUBMED: | 27149548 |
| PROVIDER: | scopus |
| PMCID: | PMC5120361 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 October 2016 -- Source: Scopus |
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