Bilateral optic neuropathy with IgGκ multiple myeloma improved after myeloablative chemotherapy Journal Article
| Authors: | Lieberman, F. S.; Odel, J.; Hirsh, J.; Heinemann, M.; Michaeli, J.; Posner, J. |
| Article Title: | Bilateral optic neuropathy with IgGκ multiple myeloma improved after myeloablative chemotherapy |
| Abstract: | A 49-year-old woman with immunoglobulin Gκ multiple myeloma developed progressive visual loss with bilateral upper and lower central arcuate scotomas. Funduscopic and electrophysiologic studies indicated bilateral optic neuropathy. The immunoglobulin G fraction of the patient's serum reacted with retinal ganglionic cells in bovine retina. The visual abnormalities remitted after myeloablative chemotherapy and disappearance of the paraprotein. |
| Keywords: | adult; cancer chemotherapy; case report; doxorubicin; antineoplastic agent; animal cell; multiple myeloma; etoposide; cyclophosphamide; dexamethasone; immunoglobulin g; cattle; retinol; immunoglobulin kappa chain; visual impairment; vitamin b complex; intravenous drug administration; ophthalmoscopy; retina ganglion cell; electroretinogram; paraprotein; optic nerve disease; thiamine; human; female; priority journal; article; central scotoma |
| Journal Title: | Neurology |
| Volume: | 52 |
| Issue: | 2 |
| ISSN: | 0028-3878 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1999-01-15 |
| Start Page: | 414 |
| End Page: | 416 |
| Language: | English |
| PUBMED: | 9932972 |
| PROVIDER: | scopus |
| DOI: | 10.1212/WNL.52.2.414 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work