Vision-targeted health-related quality of life in adult survivors of retinoblastoma Journal Article


Authors: Friedman, D. N.; Chou, J. F.; Francis, J. H.; Sklar, C. A.; Li, Y.; McCabe, M.; Robison, L. L.; Kleinerman, R. A.; Oeffinger, K. C.; Abramson, D. H.; Dunkel, I. J.; Ford, J. S.
Article Title: Vision-targeted health-related quality of life in adult survivors of retinoblastoma
Abstract: IMPORTANCE Retinoblastoma survivors are at risk for adverse oculo-visual outcomes. Limited data are available regarding long-term vision-targeted health-related quality of life (HRQoL) of adult retinoblastoma survivors. OBJECTIVE To examine vision-targeted HRQoL as reported on the 25-item National Eye Institute Visual Field Questionnaire for overall and specific scale scores among adult survivors of retinoblastoma. DESIGN, SETTING, AND PARTICIPANTS The Retinoblastoma Survivor Study is a retrospective cohort of adult retinoblastoma survivors treated at 3 academic medical centers in New York between 1932 and 1994. Participants completed a comprehensive questionnaire between April 2008 and June 2010. Items were scored in January 2013 and preliminary analyses were performed in July 2015. Models were finalized in May 2017. MAIN OUTCOMES AND MEASURES Self-reported vision-targeted HRQoL as reported on the 25-item National Eye Institute Visual Field Questionnaire. Items are scored from 0 to 100, with 100 representing the highest quality of life. RESULTS Among 470 adult retinoblastoma survivors (53.6% with bilateral disease; 52.1% female; 86.4% white and non-Hispanic; mean age at study, 43.3 years; range, 18.0-77.0 years), 86% had at least 1 eye removed (1 eye, 74.5%; both eyes, 11.5%); 56.5% were previously treated with radiotherapy; and 61.3% rated their eyesight as excellent/good while 16.2% reported complete blindness. The overall mean (SD) VFQ composite score for all survivors was 81.1 (17.2) (mean [SD] score for unilateral retinoblastoma survivors, 91.4 [7.7]; bilateral retinoblastoma survivors, 72.3 [18.2]; difference between survivors with unilateral and bilateral disease, 19.1 [95% CI, 16.5-21.7; P < .001]). Prior exposure to radiotherapy was not associated with decreased overall VFQ (ß = -0.08; 95% CI, -0.15 to 0.002; P = .06) but was related to a few specific subdomains of visual functioning. CONCLUSIONS AND RELEVANCE These findings suggest retinoblastoma-related oculo-visual problems are associated with functional status and vision-targeted HRQoL of adult survivors, particularly among those with bilateral disease. © 2018 American Medical Association. All rights reserved.
Journal Title: JAMA Ophthalmology
Volume: 136
Issue: 6
ISSN: 2168-6165
Publisher: American Medical Association  
Date Published: 2018-06-01
Start Page: 637
End Page: 641
Language: English
DOI: 10.1001/jamaophthalmol.2018.1082
PROVIDER: scopus
PMCID: PMC5933456
PUBMED: 29710339
DOI/URL:
Notes: Article -- Export Date: 2 July 2018 -- Source: Scopus
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MSK Authors
  1. Yuelin Li
    139 Li
  2. Joanne Fu-Lou Chou
    155 Chou
  3. Ira J Dunkel
    255 Dunkel
  4. Charles A Sklar
    276 Sklar
  5. Jasmine Helen Francis
    99 Francis
  6. Jennifer S Ford
    57 Ford
  7. David H Abramson
    254 Abramson
  8. Mary McCabe
    94 McCabe