Bilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report Journal Article

   


Authors: Navarrete-Dechent, C.; Monnier, J.; Marghoob, N. G.; Liopyris, K.; Busam, K. J.; Francis, J. H.; Marghoob, A. A.
Article Title: Bilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report
Abstract: Bilateral diffuse uveal melanocytic proliferation (B-DUMP) is a rare paraneoplastic syndrome typically presenting with bilateral visual loss. B-DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro-gynaecological cancer in females (mainly ovarian cancer). Cutaneous and/or mucosal involvement in patients with B-DUMP has been reported but it is not well characterised. Herein, we present a female in her 70s with diagnosis of stage IV vaginal clear-cell carcinoma and metastatic melanoma of unknown primary that developed progressive bilateral loss of visual acuity compatible with ‘B-DUMP’. Simultaneously, she developed multifocal bilateral bluish-greyish patches on the skin that were shown to have a proliferation of dermal melanocytes. We propose that the clinical and histopathologic cutaneous findings seen in patients with B-DUMP be termed ‘diffuse integumentary melanocytic proliferation (DIMP)’. © 2021 The Australasian College of Dermatologists
Keywords: paraneoplastic syndrome; dermatology; ocular; cancer; bilateral diffuse uveal melanocytic proliferation
Journal Title: Australasian Journal of Dermatology
Volume: 62
Issue: 3
ISSN: 0004-8380
Publisher: Wiley Blackwell  
Date Published: 2021-08-01
Start Page: 386
End Page: 389
Language: English
DOI: 10.1111/ajd.13617
PUBMED: 33974277
PROVIDER: scopus
PMCID: PMC9426652
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105452811&doi=10.1111%2fajd.13617&partnerID=40&md5=7f5ff8d95bdf1f7abbee5e304bda996b
Notes: Article -- Export Date: 1 October 2021 -- Source: Scopus
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MSK Authors
  1. Jasmine Helen Francis
    256 Francis
  2. Ashfaq A Marghoob
    534 Marghoob
  3. Klaus J Busam
    688 Busam
  4. Konstantinos Liopyris
    42 Liopyris
  5. Cristian Patricio Navarrete
    73 Navarrete
  6. Jilliana Monnier
    9 Monnier
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