Changes in FDG tumor uptake during and after fractionated radiation therapy in a rodent tumor xenograft Journal Article
| Authors: | Humm, J. L.; Lee, J.; O'Donoghue, J. A.; Squire, O.; Ling, C. C.; Pentlow, K.; Mehta, B.; Erdi, Y.; Ruan, S.; Larson, S. M. |
| Article Title: | Changes in FDG tumor uptake during and after fractionated radiation therapy in a rodent tumor xenograft |
| Abstract: | Objective: The uptake of FDG was measured before, during, and after fractionated radiation in order to evaluate the potential of FDG-PET imaging as an indicator of tumor response. Methods: The study was performed with nude rats bearing the human neuroblastoma BE(2)C tumor xenografts. Tumors were irradiated with 10 fractions of 2 Gy using a 320 kVp X-ray unit. Following a baseline FDG-PET scan, repeat scans were performed weekly until animal sacrifice. The rodents were given up to 10 FDG-PET scans, over a period of up to 75 days posttreatment. Results and Conclusions: Neither, the average and maximum activity/cc of FDG tumor uptake, nor the respective standardized uptake values (SUV), correlated with tumor response. Instead, the total FDG uptake (defined as the product of the average FDG activity/cc with the tumor volume) correlated better with tumor response. Copyright © 1999 Elsevier Science Inc. All rights reserved. |
| Keywords: | treatment response; positron emission tomography; radiation therapy; fluorodeoxyglucose; standardized uptake value; lesion glycolysis |
| Journal Title: | Clinical Positron Imaging |
| Volume: | 2 |
| Issue: | 5 |
| ISSN: | 1095-0397 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1999-09-01 |
| Start Page: | 289 |
| End Page: | 296 |
| Language: | English |
| DOI: | 10.1016/s1095-0397(99)00031-x |
| PROVIDER: | scopus |
| PUBMED: | 14516653 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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