Changes in FDG tumor uptake during and after fractionated radiation therapy in a rodent tumor xenograft Journal Article


Authors: Humm, J. L.; Lee, J.; O'Donoghue, J. A.; Squire, O.; Ling, C. C.; Pentlow, K.; Mehta, B.; Erdi, Y.; Ruan, S.; Larson, S. M.
Article Title: Changes in FDG tumor uptake during and after fractionated radiation therapy in a rodent tumor xenograft
Abstract: Objective: The uptake of FDG was measured before, during, and after fractionated radiation in order to evaluate the potential of FDG-PET imaging as an indicator of tumor response. Methods: The study was performed with nude rats bearing the human neuroblastoma BE(2)C tumor xenografts. Tumors were irradiated with 10 fractions of 2 Gy using a 320 kVp X-ray unit. Following a baseline FDG-PET scan, repeat scans were performed weekly until animal sacrifice. The rodents were given up to 10 FDG-PET scans, over a period of up to 75 days posttreatment. Results and Conclusions: Neither, the average and maximum activity/cc of FDG tumor uptake, nor the respective standardized uptake values (SUV), correlated with tumor response. Instead, the total FDG uptake (defined as the product of the average FDG activity/cc with the tumor volume) correlated better with tumor response. Copyright © 1999 Elsevier Science Inc. All rights reserved.
Keywords: treatment response; positron emission tomography; radiation therapy; fluorodeoxyglucose; standardized uptake value; lesion glycolysis
Journal Title: Clinical Positron Imaging
Volume: 2
Issue: 5
ISSN: 1095-0397
Publisher: Elsevier Inc.  
Date Published: 1999-09-01
Start Page: 289
End Page: 296
Language: English
DOI: 10.1016/s1095-0397(99)00031-x
PROVIDER: scopus
PUBMED: 14516653
DOI/URL:
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. John Laurence Humm
    434 Humm
  2. Yusuf E Erdi
    118 Erdi
  3. Shutian Ruan
    56 Ruan
  4. Steven M Larson
    959 Larson
  5. Keith S Pentlow
    70 Pentlow
  6. C Clifton Ling
    331 Ling
  7. Olivia D Squire
    32 Squire
  8. Bipin M Mehta
    36 Mehta
  9. Jongbin   Lee
    7 Lee