The accuracy of [(18)F]fluorodeoxyglucose positron emission tomography as confirmed by biopsy in the diagnosis of spine metastases in a cancer population Journal Article

  

Authors:	Laufer, I.; Lis, E.; Pisinski, L.; Akhurst, T.; Bilsky, M. H.
Article Title:	The accuracy of [(18)F]fluorodeoxyglucose positron emission tomography as confirmed by biopsy in the diagnosis of spine metastases in a cancer population
Abstract:	OBJECTIVE: To determine the accuracy of [F]fluorodeoxyglucose (FDG) positron emission tomography (PET) in the diagnosis of vertebral metastases in patients with cancer using needle-biopsy results and patient follow-up data. METHODS: A retrospective chart review of all patients who underwent a needle biopsy of a spinal lesion and underwent FDG-PET within 6 weeks of the biopsy was performed. Biopsy results and magnetic resonance imaging and computed tomographic appearance of the biopsied lesion, as well as long-term clinical follow-up data, were recorded for each patient. A total of 82 patients with solid tumors and hematological spine metastases were included in this study. RESULTS: The mean standardized uptake values of lesions with active cancer were 7.1 and 2.1 in benign lesions (P < 0.02). In patients with metastatic solid tumors, the mean standardized uptake value was 7.3. Stratification of solid tumor lesions according to whether they had a sclerotic appearance on computed tomographic scans showed that FDG-PET was a significantly better predictor of cancer status in lytic or mixed lesions. In patients with a history of solid tumors, there was 100% concordance between the FDG-PET and needle-biopsy diagnoses in nonsclerotic lesions, when the standardized uptake value cutoff of 2 was used. CONCLUSION: FDG-PET is an accurate screening test for vertebral metastases in cancer patients. It is especially accurate in patients with nonsclerotic vertebral lesions and a history of solid malignancy.
Keywords:	adult; controlled study; human tissue; middle aged; retrospective studies; major clinical study; histopathology; solid tumor; cancer patient; nuclear magnetic resonance imaging; positron emission tomography; follow up; diagnostic accuracy; radiopharmaceuticals; metastasis; computer assisted tomography; retrospective study; diagnostic agent; screening; biopsy, needle; needle biopsy; spinal cord tumor; spine; spinal neoplasms; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; radiopharmaceutical agent; scintiscanning; benign tumor; spinal cord lesion; [<sup>18</sup>f]fluorodeoxyglucose; sclerotic; vertebral; spine metastasis
Journal Title:	Neurosurgery
Volume:	64
Issue:	1
ISSN:	0148-396X
Publisher:	Wolters Kluwer
Date Published:	2009-01-01
Start Page:	107
End Page:	113
Language:	English
DOI:	10.1227/01.neu.0000335176.98788.a1
PUBMED:	19145159
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-62449300719&partnerID=40&md5=fb94f3c89406086c5f52c318cb3747de
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: NRSRD" - "Source: Scopus"

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