Modeling the relationship between fluorodeoxyglucose uptake and tumor radioresistance as a function of the tumor microenvironment Journal Article

   

Authors:	Jeong, J.; Deasy, J. O.
Article Title:	Modeling the relationship between fluorodeoxyglucose uptake and tumor radioresistance as a function of the tumor microenvironment
Abstract:	High fluorodeoxyglucose positron emission tomography (FDG-PET) uptake in tumors has often been correlated with increasing local failure and shorter overall survival, but the radiobiological mechanisms of this uptake are unclear. We explore the relationship between FDG-PET uptake and tumor radioresistance using a mechanistic model that considers cellular status as a function of microenvironmental conditions, including proliferating cells with access to oxygen and glucose, metabolically active cells with access to glucose but not oxygen, and severely hypoxic cells that are starving. However, it is unclear what the precise uptake levels of glucose should be for cells that receive oxygen and glucose versus cells that only receive glucose. Different potential FDG uptake profiles, as a function of the microenvironment, were simulated. Predicted tumor doses for 50% control (TD50) in 2 Gy fractions were estimated for each assumed uptake profile and for various possible cell mixtures. The results support the hypothesis of an increased avidity of FDG for cells in the intermediate stress state (those receiving glucose but not oxygen) compared to well-oxygenated (and proliferating) cells.
Keywords:	positron emission tomography; radiopharmaceuticals; neoplasms; cell proliferation; reproducibility; reproducibility of results; oxygen; chemistry; probability; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; radiopharmaceutical agent; scintiscanning; glucose blood level; glucose; blood glucose; tumor microenvironment; procedures; humans; human; diagnostic use
Journal Title:	Computational and Mathematical Methods in Medicine
Volume:	2014
ISSN:	1748-670X
Publisher:	Hindawi Publishing Corporation
Date Published:	2014-01-01
Start Page:	847162
Language:	English
DOI:	10.1155/2014/847162
PUBMED:	25276223
PROVIDER:	scopus
PMCID:	PMC4172889
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84930989385&partnerID=40&md5=865b5ffe5fda409696269a5c42d35132
Notes:	Export Date: 2 July 2015 -- Source: Scopus

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