Prostate-specific membrane antigen (PSMA)-specific monoclonal antibodies in the treatment of prostate and other cancers Journal Article


Authors: Gong, M. C.; Chang, S. S.; Sadelain, M.; Bander, N. H.; Heston, W. D. W.
Article Title: Prostate-specific membrane antigen (PSMA)-specific monoclonal antibodies in the treatment of prostate and other cancers
Abstract: Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein that is expressed by prostate epithelial cells. PSMA-specific monoclonal antibodies have been utilized to characterize the biologic function and in vivo biodistribution of PSMA. PSMA is an attractive target protein for monoclonal antibody directed imaging or therapeutics for prostate cancer since its expression is relatively restricted to prostate epithelial cells and is over-expressed in prostate cancer, including in advanced stages. Currently, clinical usage of PSMA specific monoclonal antibodies has been limited to diagnostic immunohistochemistry and imaging of patients with prostate cancer. Novel applications for these antibodies will be discussed.
Keywords: immunohistochemistry; drug efficacy; neoplasms; antigen expression; cancer immunotherapy; antineoplastic activity; angiogenesis; monoclonal antibody; prostate cancer; prostatic neoplasms; prostate specific membrane antigen; antibodies, monoclonal; immunotherapy; antigens, neoplasm; tissue distribution; antigen recognition; gene therapy; antibody specificity; glutamate carboxypeptidase ii; antigens, surface; cancer immunology; humans; human; male; priority journal; article; carboxypeptidases
Journal Title: Cancer and Metastasis Reviews
Volume: 18
Issue: 4
ISSN: 0167-7659
Publisher: Springer  
Date Published: 1999-12-01
Start Page: 483
End Page: 490
Language: English
DOI: 10.1023/a:1006308826967
PUBMED: 10855791
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Warren Heston
    89 Heston
  2. Sam S Chang
    14 Chang
  3. Michel W J Sadelain
    453 Sadelain
  4. Michael Gong
    8 Gong