Targeting novel antigens for prostate cancer treatment: Focus on prostate-specific membrane antigen Journal Article
| Author: | Slovin, S. F. |
| Article Title: | Targeting novel antigens for prostate cancer treatment: Focus on prostate-specific membrane antigen |
| Abstract: | Prostate-specific membrane antigen (PSMA) is a relatively omnipresent, but unique Type II dimeric transmembrane protein with a multiplicity of functions and has been shown to be a reasonable target for immunological approaches such as vaccines or more directed therapy with radioactively labelled monoclonal antibodies against PSMA. Given the abundance of various glycoprotein and carbohydrate antigens expressed on the surface of prostate cancer cells and cell lines, PSMA stands out as another 'self' antigen which is not only expressed on cancer cells, but on neovasculature. Although vaccines are varied in their design and target goal, recent technology has afforded researchers the opportunity to induce recruitment of multiple effector cell populations, cytokines and factors which can elicit both cellular and humoral responses. This review serves to present unique approaches in vaccine development which can induce immunological responsiveness with potential impact on disease progression and to introduce PSMA as a potential target for multimodality therapies. © 2005 Ashley Publications Ltd. |
| Keywords: | cancer chemotherapy; prednisone; clinical trial; neutropenia; review; cancer growth; nonhuman; drug targeting; protein function; antigen expression; dendritic cell vaccine; glycoprotein gp 100; interleukin 2; granulocyte macrophage colony stimulating factor; protein; cancer cell culture; cell population; drug design; docetaxel; monoclonal antibody; prostate cancer; prostatic neoplasms; cytokine; capromab pendetide in 111; prostate specific membrane antigen; cellular immunity; antigen; hybrid protein; immunotherapy; cancer vaccine; isotope labeling; cancer vaccines; cancer cell; membrane protein; mitoxantrone; glucocorticoid; effector cell; dna vaccine; granulocyte macrophage colony stimulating factor vaccine; humoral immunity; tumor vascularization; glycoprotein; vaccine; carbohydrate antigen; glutamate carboxypeptidase ii; antigens, surface; keyhole limpet hemocyanin; cell surface; qs 21; vector; replicon; dimer; prostate-specific membrane antigen (psma); bacteriophage; estramustine; acid phosphatase prostate isoenzyme; virus vaccine; prostate-specific antigen (psa); aluminum hydroxide; monoclonal antibody in 111 |
| Journal Title: | Expert Opinion on Therapeutic Targets |
| Volume: | 9 |
| Issue: | 3 |
| ISSN: | 1472-8222 |
| Publisher: | Informa Healthcare |
| Date Published: | 2005-06-01 |
| Start Page: | 561 |
| End Page: | 570 |
| Language: | English |
| DOI: | 10.1517/14728222.9.3.561 |
| PUBMED: | 15948673 |
| PROVIDER: | scopus |
| PMCID: | PMC1855285 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 17" - "Export Date: 24 October 2012" - "CODEN: EOTTA" - "Source: Scopus" |
