Emerging role of immunotherapy in the management of prostate cancer Journal Article
| Author: | Slovin, S. F. |
| Article Title: | Emerging role of immunotherapy in the management of prostate cancer |
| Abstract: | There has been a resurgence of interest in developing noncytotoxic immune therapies for patients with either hormone-naive biochemically relapsed post-primary therapy or castrate metastatic prostate cancer. The rationale for developing an immunotherapeutic approach has been based on the overexpression and underglycosylation of a wide variety of altered "self" molecules including prostate-specific antigen (PSA), acid phosphatase (ACP), prostate stem cell antigen (PSCA), and prostate-specific membrane antigen (PSMA), which can serve as targets for immune recognition and attack. In addition, such a strategy could theoretically make use of the patient's immune system to fight the tumor particularly if their disease is of reasonably low volume. A variety of immunotherapeutic approaches have been explored through phase I, II, and now phase III trials demonstrating that immunologic tolerance could be broken, as evidenced by the development of high-titer antibodies and T-cell responses specific for the tumor. What appears to be revolutionizing the immunotherapy field is the combination of vaccines with cytokines or immune modulators, which not only potentiate immune reactivity in vivo but foster dramatic antitumor responses. This review explores the challenges now faced in establishing a role for immune therapies for prostate cancer treatment. |
| Keywords: | cancer survival; treatment outcome; review; placebo; nonhuman; bone metastasis; drug megadose; prostate specific antigen; ipilimumab; cancer immunotherapy; bone marrow suppression; granulocyte macrophage colony stimulating factor; combination chemotherapy; tumor antigen; gene transfer; monoclonal antibody; fever; prostate cancer; prostatic neoplasms; cytokine; immunological tolerance; monoclonal antibody j591; prostate specific membrane antigen; rigor; hybrid protein; immunotherapy; immunoglobulin g; cancer vaccine; cancer vaccines; vaccination; recombinant protein; tumor immunity; immunomodulation; mucin 1; provenge; cytotoxic t lymphocyte antigen 4; granulocyte macrophage colony stimulating factor vaccine; indium 111; absence of side effects; yttrium; complementary dna; iodine; mucin 2; acid phosphatase prostate isoenzyme; lutetium 177 |
| Journal Title: | Oncology (Norwalk) |
| Volume: | 21 |
| Issue: | 3 |
| ISSN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 2007-03-01 |
| Start Page: | 326 |
| End Page: | 333 |
| Language: | English |
| PUBMED: | 17447437 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "CODEN: OCLGE" - "Source: Scopus" |
