Prostate-specific membrane antigen vaccines: Naked DNA and protein approaches Journal Article
| Author: | Slovin, S. F. |
| Article Title: | Prostate-specific membrane antigen vaccines: Naked DNA and protein approaches |
| Abstract: | Prostate-specific membrane antigen (PSMA) is a relatively omnipresent molecule with a multiplicity of functions and has been shown to be a reasonable target for immunologic approaches such as vaccines or more directed therapy with radioactively labeled monoclonal antibodies against PSMA. Given the abundance of various glycoprotein and carbohydrate antigens expressed on the surface of prostate cancer cells and cell lines, PSMA stands out as another self-antigen that is not only expressed on cancer cells but also on neovasculature. Although vaccines are varied in their design and target goal, recent technology has afforded researchers the opportunity to induce recruitment of multiple effector cell populations, cytokines, and factors that can elicit cellular and humoral responses. This review serves to present unique approaches in vaccine development that can induce immunologic responsiveness to PSMA with potential impact on disease progression. |
| Keywords: | unclassified drug; clinical trial; review; nonhuman; antigen expression; animals; cancer immunotherapy; cancer cell culture; viral gene delivery system; monoclonal antibody; prostate cancer; prostate-specific antigen; prostatic neoplasms; cytokine; prostate specific membrane antigen; cellular immunity; antigen; cancer vaccine; cancer vaccines; cancer immunization; recombinant protein; autoantigen; effector cell; dna vaccine; radioisotope; virus recombinant; amino acids; vaccine production; major histocompatibility complex; humoral immunity; neovascularization (pathology); vaccines, dna; glycoprotein; carbohydrate antigen; biological factor; vector; replicon; gene gun; naked dna; recombinant protein vaccine; recombinant soluble prostate specific membrane antigen vaccine; vaccine replicon particle prostate specific membrane particle |
| Journal Title: | Clinical Prostate Cancer |
| Volume: | 4 |
| Issue: | 2 |
| ISSN: | 1540-0352 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2005-09-01 |
| Start Page: | 118 |
| End Page: | 123 |
| Language: | English |
| PUBMED: | 16197613 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 24 October 2012" - "CODEN: CPCLC" - "Source: Scopus" |
