Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy Journal Article


Authors: Gong, M. C.; Chang, S. S.; Watt, F.; O'keefe, D. S.; Bacich, D. J.; Uchida, A.; Bander, N. H.; Reuter, V. E.; Gaudin, P. B.; Molloy, P. L.; Sadelain, M.; Heston, W. D. W.
Article Title: Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy
Abstract: Prostate-specific membrane antigen (PSMA) is a potential target in prostate cancer patients because it is very highly expressed and because it has been reported to be upregulated by androgen deprivation. This overview addresses the expression of the PSMA gene in terms of the promoter and enhancer and how that may play a role in gene therapy. We also review PSMA as a target for antibodies for imaging and treatment and the development of a novel hybrid T-cell receptor that combines the specificity of anti-PSMA antibodies with that of T-cell receptor activation when introduced into primary lymphocytes by retroviral-mediated gene transfer. We also discuss our recent findings on the expression of a PSMA-like gene and how that understanding allows specific targeting of PSMA.
Keywords: gene; organization; carboxypeptidase; expression; folate; hydrolase; tumor-associated neovasculature; human transferrin receptor
Journal Title: Molecular Urology
Volume: 4
Issue: 3
ISSN: 1091-5362
Publisher: Mary Ann Liebert, Inc  
Date Published: 2000-01-01
Start Page: 217
End Page: 222
Language: English
ACCESSION: WOS:000089912400030
PROVIDER: wos
PUBMED: 11062377
Notes: Presented at the 5th International Conference on Neoadjuvant Hormonal Therapy for Prostate Cancer; 2000 Mar 17-18; Cambridge, MA -- Source: Wos