Epstein-Barr virus-associated leiomyosarcoma of the thyroid in a child with congenital immunodeficiency: A case report Journal Article
| Authors: | Tulbah, A.; Al-Dayel, F.; Fawaz, I.; Rosai, J. |
| Article Title: | Epstein-Barr virus-associated leiomyosarcoma of the thyroid in a child with congenital immunodeficiency: A case report |
| Abstract: | We report an unusual case of multifocal leiomyosareoma involving the thyroid gland, liver, and right lung in a child with congenital immunodeficiency disease. The smooth muscle nature of these neoplasms was confirmed by immunohistochemistry and electron microscopic studies. In situ hybridization showed large amounts of Epstein-Barr virus messenger RNA within the tumor cells. Although Epstein-Barr virus-associated smooth muscle tumors have been reported in children with AIDS and after organ transplantation, we are unaware of any case report in congenital immunodeficiency disease. |
| Keywords: | child; child, preschool; case report; cancer risk; liver neoplasms; t-lymphocytes; lung neoplasms; in situ hybridization; tumor virus infections; thyroid cancer; thyroid neoplasms; leiomyosarcoma; immune deficiency; immunocompromised host; immunologic deficiency syndromes; epstein barr virus; rna, viral; herpesvirus 4, human; immunosuppression; virus carcinogenesis; herpesviridae infections; epstein-barr virus; humans; human; male; article; congenital immunodeficiency diseases; smooth muscle tumors |
| Journal Title: | American Journal of Surgical Pathology |
| Volume: | 23 |
| Issue: | 4 |
| ISSN: | 0147-5185 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1999-04-01 |
| Start Page: | 473 |
| End Page: | 476 |
| Language: | English |
| DOI: | 10.1097/00000478-199904000-00013 |
| PUBMED: | 10199478 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
