Epstein-Barr virus-associated multifocal leiomyosarcomas arising in a cardiac transplant recipient: Autopsy case report and review of the literature Journal Article
| Authors: | Nur, S.; Rosenblum, W. D.; Katta, U. D.; Islam, H.; Brown, K.; Ramaswamy, G. |
| Article Title: | Epstein-Barr virus-associated multifocal leiomyosarcomas arising in a cardiac transplant recipient: Autopsy case report and review of the literature |
| Abstract: | Epstein-Barr virus (EBV) associated smooth muscle tumors (SMTs) have been described in patients with acquired immune deficiency syndrome (AIDS) and, more recently, in association with immunosuppression after solid-organ transplantation. We present the autopsy findings of multiple leiomyosarcomas (LMSs) in a 24-year old man who died 18 months after undergoing orthotopic cardiac transplantation for idiopathic cardiomyopathy. The recognition of EBV-driven LMS developing in cardiac transplant recipients in multiple unusual sites is crucial for the management of these patients and should include complete surgical removal anti-viral therapy and modulation of immunosuppression. © 2007 International Society for Heart and Lung Transplantation. |
| Keywords: | adult; case report; postoperative infection; virus infection; leiomyosarcoma; immune deficiency; autopsy; neoplasms, multiple primary; epstein barr virus; herpesvirus 4, human; cardiomyopathy; immunosuppression; virus carcinogenesis; epstein-barr virus infections; fatality; smooth muscle tumor; heart transplantation; virus diagnosis |
| Journal Title: | Journal of Heart and Lung Transplantation |
| Volume: | 26 |
| Issue: | 9 |
| ISSN: | 1053-2498 |
| Publisher: | International Society for Heart and Lung Transplantation |
| Date Published: | 2007-09-01 |
| Start Page: | 944 |
| End Page: | 952 |
| Language: | English |
| DOI: | 10.1016/j.healun.2007.05.022 |
| PUBMED: | 17845934 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "CODEN: JHLTE" - "Source: Scopus" |
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