EBV-associated smooth muscle neoplasms: Solid tumors arising in the presence of immunosuppression and autoimmune diseases Journal Article
| Authors: | Moore Dalal, K.; Antonescu, C. R.; DeMatteo, R. P.; Maki, R. G. |
| Article Title: | EBV-associated smooth muscle neoplasms: Solid tumors arising in the presence of immunosuppression and autoimmune diseases |
| Abstract: | Background. Epstein-Barr virus (EBV)-related smooth muscle neoplasms (SMNs) have been associated with immune dysregulation, most notably in patients who have undergone solid organ transplantation or in patients with HIV/AIDS. Objective. to report our experience with EBV-related neoplasms as well as describing the first EBV-related SMN in the setting of administration of glucocorticoids and the tumor necrosis factor inhibitor etanercept. Design. We have case reports, of minimum 3-year follow-up, 2002-2005. Setting. It was held in an academic and tertiary referral cancer center. Patients. Patients are with dysregulated immunity after solid organ transplantation, HIV/AIDS, or with psoriasis after treatment with etanercept. Interventions. There were discontinuation of etanercept, right hepatic trisegmentectomy, and chemotherapy. Measurements. We use survival as a measurement here. Results. Patients who were able to withstand reduction in immunosuppression survived. Surgical resection or chemotherapy was successful in delaying progression of disease. Limitations. There was a relatively short follow-up for these slow-growing neoplasms. Conclusion. EBV-related SMNs have variable aggressiveness. While chemotherapy may slow disease progression, resection and improving the host immune status provide the best opportunity for primary tumor control. Copyright © 2008 Kimberly Moore Dalal et al. |
| Keywords: | adult; cancer chemotherapy; human tissue; cancer surgery; prednisone; disease course; case report; doxorubicin; drug dose reduction; drug withdrawal; disease free survival; follow up; dacarbazine; psoriasis; cancer center; lung metastasis; spinal cord tumor; etanercept; patient compliance; glucocorticoid; liver resection; azathioprine; acquired immune deficiency syndrome; penis carcinoma; cancer control; cholecystectomy; immunosuppressive treatment; autoimmune disease; mycophenolic acid 2 morpholinoethyl ester; lung biopsy; treatment refusal; cyclosporin; chronic kidney failure; epstein barr virus; patient referral; smooth muscle; host; lamivudine; kidney graft rejection; kidney transplantation; bacterial pneumonia; stavudine; immune status; immune dysregulation; mononucleosis; muscle cancer; pneumocystosis |
| Journal Title: | Sarcoma |
| Volume: | 2008 |
| ISSN: | 1357-714X |
| Publisher: | Hindawi Publishing Corporation |
| Date Published: | 2008-12-01 |
| Start Page: | 859407 |
| Language: | English |
| DOI: | 10.1155/2008/859407 |
| PROVIDER: | scopus |
| PMCID: | PMC2590677 |
| PUBMED: | 19079588 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 17 November 2011" - "CODEN: SARCF" - "Source: Scopus" |
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