Complete percutaneous excision of infiltrating carcinoma at stereotactic breast biopsy: How can tumor size be assessed? Journal Article


Authors: Liberman, L.; Zakowski, M. F.; Avery, S.; Hudis, C.; Morris, E. A.; Abramson, A. F.; LaTrenta, L. R.; Glassman, J. R.; Dershaw, D. D.
Article Title: Complete percutaneous excision of infiltrating carcinoma at stereotactic breast biopsy: How can tumor size be assessed?
Abstract: OBJECTIVE. The purpose of this study was to determine the frequency of complete excision of infiltrating carcinoma at stereotactic 11-gauge directional vacuum-assisted breast biopsy and to evaluate the feasibility of measuring tumor size in stereotactic biopsy specimens in infiltrating carcinomas that were percutaneously excised. MATERIALS AND METHODS. We performed retrospective review of 51 infiltrating carcinomas diagnosed using stereotactic 11-gauge directional vacuum-assisted biopsy that underwent subsequent surgery. For lesions yielding no residual infiltrating carcinoma at surgery, the maximal dimension of the tumor was measured in stereotactic biopsy specimens using ocular micrometry. RESULTS. In 10 (20%) (95% confidence intervals, 9.8-33.1%) of 51 infiltrating carcinomas diagnosed at stereotactic biopsy, surgery revealed no residual infiltrating carcinoma. Complete excision of infiltrating carcinoma was more frequent if 14 or more specimens were obtained (32% versus 0%, p < .004), if the mammographic lesion was removed (35% versus 7%, p < .03), and if the mammographic lesion size measured 0.7 cm or less (50% versus 16%, p = .08). Tumor size in stereotactic biopsy specimens was within 3 mm of mammographic lesion size in six (60%) of 10 lesions, including five (71%) of seven masses and one (33%) of three calcification lesions, but was smaller than the mammographic lesion size in eight (80%) of 10 lesions. CONCLUSION. Surgery revealed no residual infiltrating carcinoma in 10 (20%) of 51 infiltrating carcinomas diagnosed at stereotactic 11-gauge biopsy. Although tumor size can be assessed in stereotactic biopsy specimens in these lesions, such measurements may underestimate the maximal dimension of the tumor. Further study is needed to evaluate the usefulness of these measurements in guiding treatment decisions.
Keywords: adult; aged; middle aged; major clinical study; sensitivity and specificity; medical decision making; tumor volume; breast neoplasms; retrospective study; mammography; feasibility studies; biopsy, needle; breast carcinoma; carcinoma in situ; equipment design; mastectomy, segmental; breast biopsy; carcinoma, ductal, breast; stereotaxic surgery; calcinosis; humans; human; female; priority journal; article
Journal Title: American Journal of Roentgenology
Volume: 173
Issue: 5
ISSN: 0361-803X
Publisher: American Roentgen Ray Society  
Date Published: 1999-11-01
Start Page: 1315
End Page: 1322
Language: English
PUBMED: 10541111
PROVIDER: scopus
DOI: 10.2214/ajr.173.5.10541111
DOI/URL:
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. D David Dershaw
    223 Dershaw
  2. Clifford Hudis
    905 Hudis
  3. Laura Liberman
    176 Liberman
  4. Elizabeth A Morris
    342 Morris
  5. Maureen F Zakowski
    289 Zakowski
  6. Sharon Avery
    6 Avery