Stereotactic II-gauge vacuum-assisted breast biopsy: A validation study Journal Article


Authors: Pfarl, G.; Helbich, T. H.; Riedl, C. C.; Wagner, T.; Gnant, M.; Rudas, M.; Liberman, L.
Article Title: Stereotactic II-gauge vacuum-assisted breast biopsy: A validation study
Abstract: OBJECTIVE. The aim of our study was to determine the false-negative rate of stereotactic 11-gauge vacuum-assisted biopsy in a validation study of lesions that had subsequent surgical excision. MATERIALS AND METHODS. Retrospective review was performed of 318 lesions that underwent stereotactic 11-gauge vacuum-assisted biopsy and subsequent surgical excision. A false-negative case was defined as a pathologically proven cancer in which stereotactic biopsy yielded benign results without atypia. Medical records, imaging studies, and histologic findings were reviewed. RESULTS. False-negative findings were encountered at stereotactic 11-gauge vacuum-assisted biopsy in 3.3% (7/214) of pathologically proven cancers. False-negative findings occurred in 3.5% (4/115) of malignant calcification lesions versus 3.0% (3/99) of malignant masses (p = 1.0). The seven false-negative findings included five Breast Imaging Reporting and Data System (BI-RADS) category 5 lesions that yielded benign results at biopsy, one BIRADS category 4 mass that yielded benign breast tissue, and one BI-RADS category 4 cluster of calcifications in which no calcifications were retrieved. The false-negative rate was 10.0% (6/60) for radiologists who performed 15 or fewer previous stereotactic vacuum-assisted biopsy procedures versus 0.6% (1/154) for radiologists who performed more than 15 previous stereotactic vacuum-assisted biopsy procedures (p = 0.002). CONCLUSION. Stereotactic 11-gauge vacuum-assisted biopsy had a false-negative rate of 3.3% that diminished to 0.6% with experience. All false-negative findings could be prospectively identified because of failure to sample calcifications or imaging-histologic discordance.
Keywords: adult; human tissue; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; methodology; laboratory diagnosis; breast cancer; breast; pathology; validation study; breast neoplasms; retrospective study; histology; instrumentation; biopsy, needle; breast tumor; needle biopsy; false negative reactions; breast biopsy; breast disease; stereotaxic surgery; calcinosis; breast hyperplasia; breast calcification; stereotaxic techniques; humans; human; female; priority journal; article
Journal Title: American Journal of Roentgenology
Volume: 179
Issue: 6
ISSN: 0361-803X
Publisher: American Roentgen Ray Society  
Date Published: 2002-12-01
Start Page: 1503
End Page: 1507
Language: English
PUBMED: 12438044
PROVIDER: scopus
DOI: 10.2214/ajr.179.6.1791503
DOI/URL:
Notes: Export Date: 14 November 2014 -- Source: Scopus
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  1. Laura Liberman
    172 Liberman