Calcification retrieval at stereotactic, 11-gauge, directional, vacuum- assisted breast biopsy Journal Article


Authors: Liberman, L.; Smolkin, J. H.; Dershaw, D. D.; Morris, E. A.; Abramson, A. F.; Rosen, P. P.
Article Title: Calcification retrieval at stereotactic, 11-gauge, directional, vacuum- assisted breast biopsy
Abstract: PURPOSE: To determine the frequencies of calcification retrieval and histologic underestimates at stereotactic, 11-gauge, directional, vacuum- assisted breast biopsy. MATERIALS AND METHODS: Retrospective review of records revealed 112 calcific lesions in 80 women (aged 31-85 years) who underwent stereotactic, 11-gauge, directional, vacuum-assisted biopsy; a mean of 14 specimens per lesion were obtained. Calcification retrieval was defined as identification of calcifications on radiographs of specimens. Atypical ductal hyperplasia (ADH) underestimates were lesions that yielded ADH at stereotactic biopsy and carcinoma at surgery. Ductal carcinoma in situ (DCIS) underestimates were lesions that yielded DCIS at stereotactic biopsy and infiltrating carcinoma at surgery. Mammograms, stereotactic images, radiographs of specimens, and histologic findings were reviewed. RESULTS: Stereotactic, 11-gauge, directional, vacuum-assisted biopsy removed all calcifications in 51 (46%) lesions, some calcifications in 55 (49%) lesions, and no calcifications in six (5%) lesions. Failure to retrieve calcifications was significantly more likely in lesions 5 mm or smaller (12% [five of 43] vs 1% [one of 69], P = .03), in calcifications with amorphous morphology (21% [three of 14] vs 3% [three of 98], P < .03), or if the probe was fired outside the breast (12% [five of 40] vs 1% [one of 72], P = .02). Surgery revealed DCIS in one (10%) of 10 lesions that yielded ADH at stereotactic biopsy. Surgery revealed infiltrating carcinoma in one (5%) of 21 lesions that yielded DCIS at stereotactic biopsy. No underestimation occurred when all calcifications were removed. CONCLUSION: Stereotactic, 11-gauge, directional, vacuum-assisted biopsy resulted in successful calcification retrieval in 106 (95%) of 112 cases. Histologic underestimation was infrequent.
Keywords: adult; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; clinical trial; cancer diagnosis; breast cancer; breast; breast neoplasms; mammography; biopsy, needle; carcinoma in situ; hyperplasia; carcinoma; radiography, interventional; neoplasm invasiveness; breast biopsy; calcification; vacuum; carcinoma, ductal, breast; stereotaxic surgery; calcinosis; stereotaxic techniques; humans; human; female; priority journal; article; breast neoplasms, diagnosis; breast neoplasms, biopsy; breast neoplasms, radiography; breast, calcification; specimen, radiography
Journal Title: Radiology
Volume: 208
Issue: 1
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 1998-07-01
Start Page: 251
End Page: 260
Language: English
PUBMED: 9646821
PROVIDER: scopus
DOI: 10.1148/radiology.208.1.9646821
DOI/URL:
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
Altmetric Score
MSK Authors
  1. D David Dershaw
    186 Dershaw
  2. Laura Liberman
    171 Liberman
  3. Jennifer Menell
    16 Menell
  4. Elizabeth A Morris
    262 Morris
  5. Paul P Rosen
    122 Rosen