Epithelial displacement after stereotactic 11-gauge directional vacuum- assisted breast biopsy Journal Article


Authors: Liberman, L.; Vuolo, M.; Dershaw, D. D.; Morris, E. A.; Abramson, A. F.; LaTrenta, L. R.; Polini, N. M.; Rosen, P. P.
Article Title: Epithelial displacement after stereotactic 11-gauge directional vacuum- assisted breast biopsy
Abstract: OBJECTIVE. Displaced epithelial fragments at percutaneous biopsy of ductal carcinoma in situ (DCIS) may mimic stromal invasion. This study was undertaken to determine the frequency of epithelial displacement in DCIS lesions of patients who underwent stereotactic 11-gauge directional vacuum- assisted breast biopsy. MATERIALS AND METHODS. We retrospectively reviewed 28 consecutive DCIS lesions in patients who underwent stereotactic 11-gauge directional vacuum-assisted breast biopsy followed by surgery. Surgical specimens were examined for histologic evidence of epithelial displacement, consisting of fragments of epithelium in artifactual spaces in breast parenchyma or in lymphovascular channels, accompanied by hemorrhage, fat necrosis, inflammation, hemosiderin-laden macrophages, or granulation tissue. RESULTS. The median number of specimens obtained per lesion was 14 (range, seven to 45). The median interval from stereotactic biopsy to surgery was 27 days (range, 10-59 days). Surgery revealed DCIS in 19 (68%) of 28 lesions, DCIS and infiltrating carcinoma in four lesions (14%), and no residual carcinoma in five lesions (18%). Reactive changes at the biopsy site were identified in all cases. Displacement of benign epithelium into granulation tissue at the stereotactic biopsy site was identified in two cases (7%). We found no evidence of displacement of malignant epithelium. CONCLUSION. Epithelial displacement is uncommon after stereotactic 11-gauge directional vacuum-assisted biopsy of the breast. We observed displacement of benign epithelium in two (7%) of 28 DCIS lesions and no displacement of malignant epithelium.
Keywords: adult; clinical article; human tissue; aged; middle aged; retrospective studies; diagnostic accuracy; breast; breast neoplasms; biopsy, needle; breast carcinoma; carcinoma in situ; epithelium; breast biopsy; vacuum; sampling; carcinoma, ductal, breast; stereotaxic surgery; stereotaxic techniques; humans; human; female; priority journal; article
Journal Title: American Journal of Roentgenology
Volume: 172
Issue: 3
ISSN: 0361-803X
Publisher: American Roentgen Ray Society  
Date Published: 1999-03-01
Start Page: 677
End Page: 681
Language: English
PUBMED: 10063859
PROVIDER: scopus
DOI: 10.2214/ajr.172.3.10063859
DOI/URL:
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. D David Dershaw
    223 Dershaw
  2. Laura Liberman
    176 Liberman
  3. Elizabeth A Morris
    341 Morris
  4. Paul P Rosen
    201 Rosen
  5. Magalis A Vuolo
    7 Vuolo
  6. Nicole M Polini
    1 Polini