Vascular influence on ventral telencephalic progenitors and neocortical interneuron production Journal Article

   

Authors:	Tan, X.; Liu, W. A.; Zhang, X. J.; Shi, W.; Ren, S. Q.; Li, Z.; Brown, K. N.; Shi, S. H.
Article Title:	Vascular influence on ventral telencephalic progenitors and neocortical interneuron production
Abstract:	The neocortex contains glutamatergic excitatory neurons and γ-aminobutyric acid (GABA)ergic inhibitory interneurons. Extensive studies have revealed substantial insights into excitatory neuron production. However, our knowledge of the generation of GABAergic interneurons remains limited. Here we show that periventricular blood vessels selectively influence neocortical interneuron progenitor behavior and neurogenesis. Distinct from those in the dorsal telencephalon, radial glial progenitors (RGPs) in the ventral telencephalon responsible for producing neocortical interneurons progressively grow radial glial fibers anchored to periventricular vessels. This progenitor-vessel association is robust and actively maintained as RGPs undergo interkinetic nuclear migration and divide at the ventricular zone surface. Disruption of this association by selective removal of INTEGRIN β1 in RGPs leads to a decrease in progenitor division, a loss of PARVALBUMIN and SOMATOSTATIN-expressing interneurons, and defective synaptic inhibition in the neocortex. These results highlight a prominent interaction between RGPs and periventricular vessels important for proper production and function of neocortical interneurons. © 2016 Elsevier Inc.
Journal Title:	Developmental Cell
Volume:	36
Issue:	6
ISSN:	1534-5807
Publisher:	Cell Press
Date Published:	2016-03-21
Start Page:	624
End Page:	638
Language:	English
DOI:	10.1016/j.devcel.2016.02.023
PROVIDER:	scopus
PMCID:	PMC4806403
PUBMED:	27003936
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84961247624&partnerID=40&md5=5c117964b51ffdeacf87fc9b5b41c91b
Notes:	Article -- Export Date: 4 April 2016 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/90350