Clonal production and organization of inhibitory interneurons in the neocortex Journal Article
| Authors: | Brown, K. N.; Chen, S.; Han, Z.; Lu, C. H.; Tan, X.; Zhang, X. J.; Ding, L.; Lopez-Cruz, A.; Saur, D.; Anderson, S. A.; Huang, K.; Shi, S. H. |
| Article Title: | Clonal production and organization of inhibitory interneurons in the neocortex |
| Abstract: | The neocortex contains excitatory neurons and inhibitory interneurons. Clones of neocortical excitatory neurons originating from the same progenitor cell are spatially organized and contribute to the formation of functional microcircuits. In contrast, relatively little is known about the production and organization of neocortical inhibitory interneurons. We found that neocortical inhibitory interneurons were produced as spatially organized clonal units in the developing ventral telencephalon. Furthermore, clonally related interneurons did not randomly disperse but formed spatially isolated clusters in the neocortex. Individual clonal clusters consisting of interneurons expressing the same or distinct neurochemical markers exhibited clear vertical or horizontal organization. These results suggest that the lineage relationship plays a pivotal role in the organization of inhibitory interneurons in the neocortex. |
| Keywords: | controlled study; nonhuman; mitosis; animal cell; mouse; cytology; animals; mice; developmental biology; inhibitor; physiology; cell lineage; stem cell; brain; biomarker; interneuron; mammal; interneurons; beta galactosidase; cell movement; glia cell; neuroglia; neocortex; gene knock-in techniques; cell clone; biochemistry; neural stem cells; nestin; neurogenesis; clone cells; retrovirus infection; neurology; telencephalon; 4 aminobutyric acid; neural inhibition; preoptic area |
| Journal Title: | Science |
| Volume: | 334 |
| Issue: | 6055 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2011-10-28 |
| Start Page: | 480 |
| End Page: | 486 |
| Language: | English |
| DOI: | 10.1126/science.1208884 |
| PUBMED: | 22034427 |
| PROVIDER: | scopus |
| PMCID: | PMC3304494 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "CODEN: SCIEA" - "Source: Scopus" |
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